Literature DB >> 3361302

Depletion of brain glutathione in preweanling mice by L-buthionine sulfoximine.

A Slivka1, M B Spina, H I Calvin, G Cohen.   

Abstract

Previous studies indicated that DL-buthionine sulfoximine (DL-BSO), an agent that inhibits the biosynthesis of GSH in liver and other peripheral organs, fails to suppress levels of GSH in the CNS. In the current study, preweanling mice responded to repeated injections of L-BSO with marked declines (79.6-86.5%) of GSH content in brain and spinal cord. In adult mice, the same treatment schedule produced only modest declines (17.8-29.2%) of GSH content in brain and a 55.9% decline in spinal cord. Pretreatment of preweanling mice with L-BSO represents a tool for studying the role of GSH in the CNS.

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Year:  1988        PMID： 3361302     DOI： 10.1111/j.1471-4159.1988.tb03021.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  6 in total

1.  Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration.

Authors:  Weiyi Feng; Mariana Rosca; Yuxuan Fan; Yufen Hu; Pingfu Feng; Hyoung-Gon Lee; Vincent M Monnier; Xingjun Fan
Journal:  Hum Mol Genet       Date:  2017-04-01       Impact factor: 6.150

2.  Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress.

Authors:  J Mårtensson; A Jain; E Stole; W Frayer; P A Auld; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

3.  Glutathione deficiency leads to mitochondrial damage in brain.

Authors:  A Jain; J Mårtensson; E Stole; P A Auld; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

4.  PKCδ-dependent p47phox activation mediates methamphetamine-induced dopaminergic neurotoxicity.

Authors:  Duy-Khanh Dang; Eun-Joo Shin; Dae-Joong Kim; Hai-Quyen Tran; Ji Hoon Jeong; Choon-Gon Jang; Ole Petter Ottersen; Seung-Yeol Nah; Jau-Shyong Hong; Toshitaka Nabeshima; Hyoung-Chun Kim
Journal:  Free Radic Biol Med       Date:  2017-12-18       Impact factor: 7.376

5.  Effects of exogenous factors on the cerebral glutathione in rodents.

Authors:  E Bien; K Vick; G Skorka
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

6.  Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration.

Authors:  S J Heales; S E Davies; T E Bates; J B Clark
Journal:  Neurochem Res       Date:  1995-01       Impact factor: 3.996
  6 in total

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