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Literature DB >> 33612547

Sex Differences of Brain Functional Topography Revealed in Normal Aging and Alzheimer's Disease Cohort.

Filippo Cieri¹, Zhengshi Yang¹, Dietmar Cordes¹, Jessica Z K Caldwell¹.

Abstract

We applied graph theory analysis on resting-state functional magnetic resonance imaging data to evaluate sex differences of brain functional topography in normal controls (NCs), early mild cognitive impairment (eMCI), and AD patients. These metrics were correlated with RAVLT verbal learning and memory scores. The results show NCs have better functional connectivity (FC) metrics than eMCI and AD, and NC women show worse FC metrics compared to men, despite performing better on the RAVLT. FC differences between men and women diminished in eMCI and disappeared in AD. Within women, better FC metrics relate to better RAVLT learning in NCs and eMCI groups.

Entities: Chemical

Keywords: Alzheimer’s disease; brain imaging; functional connectivity; graph theory; mild cognitive impairment; rey auditory verbal learning test; sex differences

Mesh：

Year: 2021 PMID： 33612547 PMCID： PMC8793667 DOI： 10.3233/JAD-201596

Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.160

21 in total

1. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.

Authors: N Tzourio-Mazoyer; B Landeau; D Papathanassiou; F Crivello; O Etard; N Delcroix; B Mazoyer; M Joliot
Journal: Neuroimage Date: 2002-01 Impact factor: 6.556

Review 2. Disconnexion syndromes in animals and man. I.

Authors: N Geschwind
Journal: Brain Date: 1965-06 Impact factor: 13.501

3. A robust deep neural network for denoising task-based fMRI data: An application to working memory and episodic memory.

Authors: Zhengshi Yang; Xiaowei Zhuang; Karthik Sreenivasan; Virendra Mishra; Tim Curran; Dietmar Cordes
Journal: Med Image Anal Date: 2019-11-26 Impact factor: 8.545

4. Modifications in resting state functional anticorrelation between default mode network and dorsal attention network: comparison among young adults, healthy elders and mild cognitive impairment patients.

Authors: Roberto Esposito; Filippo Cieri; Piero Chiacchiaretta; Nicoletta Cera; Mariella Lauriola; Massimo Di Giannantonio; Armando Tartaro; Antonio Ferretti
Journal: Brain Imaging Behav Date: 2018-02 Impact factor: 3.978

5. Age- and gender-related differences in the cortical anatomical network.

Authors: Gaolang Gong; Pedro Rosa-Neto; Felix Carbonell; Zhang J Chen; Yong He; Alan C Evans
Journal: J Neurosci Date: 2009-12-16 Impact factor: 6.167

Review 6. Methods for cleaning the BOLD fMRI signal.

Authors: César Caballero-Gaudes; Richard C Reynolds
Journal: Neuroimage Date: 2016-12-09 Impact factor: 6.556

7. Influence of sex differences in interpreting learning and memory within a clinical sample of older adults.

Authors: Hannah E Brunet; Jessica Z K Caldwell; Jason Brandt; Justin B Miller
Journal: Neuropsychol Dev Cogn B Aging Neuropsychol Cogn Date: 2019-01-20

8. Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy.

Authors: Thomas E Cope; Timothy Rittman; Robin J Borchert; P Simon Jones; Deniz Vatansever; Kieren Allinson; Luca Passamonti; Patricia Vazquez Rodriguez; W Richard Bevan-Jones; John T O'Brien; James B Rowe
Journal: Brain Date: 2018-02-01 Impact factor: 13.501

4. Relationship of sex differences in cortical thickness and memory among cognitively healthy subjects and individuals with mild cognitive impairment and Alzheimer disease.

Authors: Filippo Cieri; Xiaowei Zhuang; Dietmar Cordes; Nikki Kaplan; Jeffery Cummings; Jessica Caldwell
Journal: Alzheimers Res Ther Date: 2022-02-22 Impact factor: 6.982

4 in total

Sex Differences of Brain Functional Topography Revealed in Normal Aging and Alzheimer's Disease Cohort.

1. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.

Review 2. Disconnexion syndromes in animals and man. I.

3. A robust deep neural network for denoising task-based fMRI data: An application to working memory and episodic memory.

4. Modifications in resting state functional anticorrelation between default mode network and dorsal attention network: comparison among young adults, healthy elders and mild cognitive impairment patients.

5. Age- and gender-related differences in the cortical anatomical network.

Review 6. Methods for cleaning the BOLD fMRI signal.

7. Influence of sex differences in interpreting learning and memory within a clinical sample of older adults.

8. Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy.

9. Moderating effects of sex on the impact of diagnosis and amyloid positivity on verbal memory and hippocampal volume.

10. Robust Motion Regression of Resting-State Data Using a Convolutional Neural Network Model.

1. Brain functional topology differs by sex in cognitively normal older adults.

2. Memory for the Future: Psychodynamic Approach to Time and Self Through the Default Network.

3. Sex Modulates the Pathological Aging Effect on Caudate Functional Connectivity in Mild Cognitive Impairment.

4. Relationship of sex differences in cortical thickness and memory among cognitively healthy subjects and individuals with mild cognitive impairment and Alzheimer disease.