Soheila Jangjo-Borazjani1, Maryam Dastgheib1, Efat Kiyamarsi1, Roghayeh Jamshidi1, Saleh Rahmati-Ahmadabad2, Masoumeh Helalizadeh3, Roya Iraji4, Stephen M Cornish5, Shiva Mohammadi-Darestani6, Zohreh Khojasteh6, Mohammad Ali Azarbayjani6. 1. Department of Physical Education and Sport Sciences, Bushehr Branch, Islamic Azad University, Bushehr, Iran. 2. Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran. 3. Department of Exercise Physiology, Sport Medicine Research Center, Sport Sciences Research Institute, Tehran, Iran. 4. Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada. 5. Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, Canada. 6. Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Abstract
CONTEXT: Proper nutrition and exercise are effective strategies to improve overall metabolic health in diabetic patients. OBJECTIVE: This study evaluated the effects of Nigella sativa (NS) supplementation during resistance training (RT) on some biochemical variables in type 2 diabetes patients. METHODS: Forty patients were assigned to groups: RT + NS (RN), NS, RT + placebo (RP), and control (CO). RT was performed and NS was consumed for 8 weeks. Blood samples were collected at rest immediately before and after the 8 week intervention. RESULTS: RT or NS by themselves reduced HOMA-IR, insulin, glucose, TG, TC, LDL, ESR, CRP, AST, ALT and ALP, and increased HDL and HOMA-S. The combination of RT and NS, rather than each intervention alone, had significant effects on reduction of HOMA-IR, insulin, ESR and CRP as well as increases in HDL, HOMA-β/S. CONCLUSION: RT combined with NS is sometimes a better strategy compared to single interventions for improving diabetes related biomarkers in type 2 diabetic patients.
CONTEXT: Proper nutrition and exercise are effective strategies to improve overall metabolic health in diabetic patients. OBJECTIVE: This study evaluated the effects of Nigella sativa (NS) supplementation during resistance training (RT) on some biochemical variables in type 2 diabetes patients. METHODS: Forty patients were assigned to groups: RT + NS (RN), NS, RT + placebo (RP), and control (CO). RT was performed and NS was consumed for 8 weeks. Blood samples were collected at rest immediately before and after the 8 week intervention. RESULTS: RT or NS by themselves reduced HOMA-IR, insulin, glucose, TG, TC, LDL, ESR, CRP, AST, ALT and ALP, and increased HDL and HOMA-S. The combination of RT and NS, rather than each intervention alone, had significant effects on reduction of HOMA-IR, insulin, ESR and CRP as well as increases in HDL, HOMA-β/S. CONCLUSION: RT combined with NS is sometimes a better strategy compared to single interventions for improving diabetes related biomarkers in type 2 diabetic patients.
Entities:
Keywords:
C-reactive protein (CRP); erythrocyte sedimentation rate (ESR); high density lipoprotein (HDL); insulin; metabolic health
Authors: Kaushik Chattopadhyay; Haiquan Wang; Jaspreet Kaur; Gamze Nalbant; Abdullah Almaqhawi; Burak Kundakci; Jeemon Panniyammakal; Michael Heinrich; Sarah Anne Lewis; Sheila Margaret Greenfield; Nikhil Tandon; Tuhin Kanti Biswas; Sanjay Kinra; Jo Leonardi-Bee Journal: Front Pharmacol Date: 2022-06-08 Impact factor: 5.988