Literature DB >> 33611523

Improving the delivery of palliative care through predictive modeling and healthcare informatics.

Dennis H Murphree1,2, Patrick M Wilson1, Shusaku W Asai1, Daniel J Quest3, Yaxiong Lin3, Piyush Mukherjee3, Nirmal Chhugani3, Jacob J Strand4, Gabriel Demuth1, David Mead3, Brian Wright3, Andrew Harrison5, Jalal Soleimani5, Vitaly Herasevich5, Brian W Pickering5, Curtis B Storlie1,2.   

Abstract

OBJECTIVE: Access to palliative care (PC) is important for many patients with uncontrolled symptom burden from serious or complex illness. However, many patients who could benefit from PC do not receive it early enough or at all. We sought to address this problem by building a predictive model into a comprehensive clinical framework with the aims to (i) identify in-hospital patients likely to benefit from a PC consult, and (ii) intervene on such patients by contacting their care team.
MATERIALS AND METHODS: Electronic health record data for 68 349 inpatient encounters in 2017 at a large hospital were used to train a model to predict the need for PC consult. This model was published as a web service, connected to institutional data pipelines, and consumed by a downstream display application monitored by the PC team. For those patients that the PC team deems appropriate, a team member then contacts the patient's corresponding care team.
RESULTS: Training performance AUC based on a 20% holdout validation set was 0.90. The most influential variables were previous palliative care, hospital unit, Albumin, Troponin, and metastatic cancer. The model has been successfully integrated into the clinical workflow making real-time predictions on hundreds of patients per day. The model had an "in-production" AUC of 0.91. A clinical trial is currently underway to assess the effect on clinical outcomes.
CONCLUSIONS: A machine learning model can effectively predict the need for an inpatient PC consult and has been successfully integrated into practice to refer new patients to PC.
© The Author(s) 2021. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  clinical; decision support systems; machine learning; palliative care; precision medicine

Mesh:

Year:  2021        PMID: 33611523      PMCID: PMC8661428          DOI: 10.1093/jamia/ocaa211

Source DB:  PubMed          Journal:  J Am Med Inform Assoc        ISSN: 1067-5027            Impact factor:   4.497


  15 in total

1.  Transitions to palliative care in acute hospitals in England: qualitative study.

Authors:  Merryn Gott; Christine Ingleton; Michael I Bennett; Clare Gardiner
Journal:  BMJ Support Palliat Care       Date:  2011-06       Impact factor: 3.568

2.  Receiver operating characteristic (ROC) curve for medical researchers.

Authors:  Rajeev Kumar; Abhaya Indrayan
Journal:  Indian Pediatr       Date:  2011-04       Impact factor: 1.411

3.  Deploying Predictive Models In A Healthcare Environment - An Open Source Approach.

Authors:  Dennis H Murphree; Daniel J Quest; Ryan M Allen; Che Ngufor; Curtis B Storlie
Journal:  Annu Int Conf IEEE Eng Med Biol Soc       Date:  2018-07

Review 4.  The relative accuracy of the clinical estimation of the duration of life for patients with end of life cancer.

Authors:  A Viganò; M Dorgan; E Bruera; M E Suarez-Almazor
Journal:  Cancer       Date:  1999-07-01       Impact factor: 6.860

5.  The role of palliative care at the end of life.

Authors:  Robin B Rome; Hillary H Luminais; Deborah A Bourgeois; Christopher M Blais
Journal:  Ochsner J       Date:  2011

6.  Extent and determinants of error in doctors' prognoses in terminally ill patients: prospective cohort study.

Authors:  N A Christakis; E B Lamont
Journal:  BMJ       Date:  2000-02-19

Review 7.  Understanding Palliative Care and Hospice: A Review for Primary Care Providers.

Authors:  Mary K Buss; Laura K Rock; Ellen P McCarthy
Journal:  Mayo Clin Proc       Date:  2017-02       Impact factor: 7.616

Review 8.  Dying in the hospital setting: A meta-synthesis identifying the elements of end-of-life care that patients and their families describe as being important.

Authors:  Claudia Virdun; Tim Luckett; Karl Lorenz; Patricia M Davidson; Jane Phillips
Journal:  Palliat Med       Date:  2016-12-08       Impact factor: 4.762

9.  Gradient boosting machines, a tutorial.

Authors:  Alexey Natekin; Alois Knoll
Journal:  Front Neurorobot       Date:  2013-12-04       Impact factor: 2.650

10.  The Growth of Palliative Care in U.S. Hospitals: A Status Report.

Authors:  Tamara Dumanovsky; Rachel Augustin; Maggie Rogers; Katrina Lettang; Diane E Meier; R Sean Morrison
Journal:  J Palliat Med       Date:  2015-09-29       Impact factor: 2.947

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  3 in total

1.  Palliative Care Exposure Relative to Predicted Risk of Six-Month Mortality in Hospitalized Adults.

Authors:  Rajiv Agarwal; Henry J Domenico; Sreenivasa R Balla; Daniel W Byrne; Jennifer G Whisenant; Marcella C Woods; Barbara J Martin; Mohana B Karlekar; Marc L Bennett
Journal:  J Pain Symptom Manage       Date:  2022-01-23       Impact factor: 5.576

2.  Development and Structure of an Accurate Machine Learning Algorithm to Predict Inpatient Mortality and Hospice Outcomes in the Coronavirus Disease 2019 Era.

Authors:  Stephen Chi; Aixia Guo; Kevin Heard; Seunghwan Kim; Randi Foraker; Patrick White; Nathan Moore
Journal:  Med Care       Date:  2022-05-01       Impact factor: 2.983

3.  Expected clinical utility of automatable prediction models for improving palliative and end-of-life care outcomes: Toward routine decision analysis before implementation.

Authors:  Ryeyan Taseen; Jean-François Ethier
Journal:  J Am Med Inform Assoc       Date:  2021-10-12       Impact factor: 4.497

  3 in total

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