Salim Si-Mohamed1, Sara Boccalini2, Pierre-Antoine Rodesch3, Riham Dessouky4, Elias Lahoud5, Thomas Broussaud3, Monica Sigovan3, Delphine Gamondes6, Philippe Coulon7, Yoad Yagil5, Loïc Boussel2, Philippe Douek2. 1. Claude-Bernard University Lyon 1, CREATIS, CNRS UMR 5220, INSERM U1206, INSA-Lyon, 69621 Villeurbanne cedex, France; Department of Radiology, Hospices Civils de Lyon, 69000 Lyon, France. Electronic address: salim.si-mohamed@chu-lyon.fr. 2. Claude-Bernard University Lyon 1, CREATIS, CNRS UMR 5220, INSERM U1206, INSA-Lyon, 69621 Villeurbanne cedex, France; Department of Radiology, Hospices Civils de Lyon, 69000 Lyon, France. 3. Claude-Bernard University Lyon 1, CREATIS, CNRS UMR 5220, INSERM U1206, INSA-Lyon, 69621 Villeurbanne cedex, France. 4. Claude-Bernard University Lyon 1, CREATIS, CNRS UMR 5220, INSERM U1206, INSA-Lyon, 69621 Villeurbanne cedex, France; Department of Radiology, Faculty of Medicine, Zagazig University, 44519 Zagazig, Egypt. 5. Global Advanced Technologies, CT, Philips Research, 34900 Haifa, Israel. 6. Department of Radiology, Hospices Civils de Lyon, 69000 Lyon, France. 7. Global Advanced Technologies, CT, Philips Research, 92000 Suresnes, France.
Abstract
PURPOSE: The purpose of this study was to characterize the technical capabilities and feasibility of a large field-of-view clinical spectral photon-counting computed tomography (SPCCT) prototype for high-resolution (HR) lung imaging. MATERIALS AND METHODS: Measurement of modulation transfer function (MTF) and acquisition of a line pairs phantom were performed. An anthropomorphic lung nodule phantom was scanned with standard (120kVp, 62mAs), low (120kVp, 11mAs), and ultra-low (80kVp, 3mAs) radiation doses. A human volunteer underwent standard (120kVp, 63mAs) and low (120kVp, 11mAs) dose scans after approval by the ethics committee. HR images were reconstructed with 1024 matrix, 300mm field of view and 0.25mm slice thickness using a filtered-back projection (FBP) and two levels of iterative reconstruction (iDose 5 and 9). The conspicuity and sharpness of various lung structures (distal airways, vessels, fissures and proximal bronchial wall), image noise, and overall image quality were independently analyzed by three radiologists and compared to a previous HR lung CT examination of the same volunteer performed with a conventional CT equipped with energy integrating detectors (120kVp, 10mAs, FBP). RESULTS: Ten percent MTF was measured at 22.3lp/cm with a cut-off at 31lp/cm. Up to 28lp/cm were depicted. While mixed and solid nodules were easily depicted on standard and low-dose phantom images, higher iDose levels and slice thicknesses (1mm) were needed to visualize ground-glass components on ultra-low-dose images. Standard dose SPCCT images of in vivo lung structures were of greater conspicuity and sharpness, with greater overall image quality, and similar image noise (despite a flux reduction of 23%) to conventional CT images. Low-dose SPCCT images were of greater or similar conspicuity and sharpness, similar overall image quality, and lower but acceptable image noise (despite a flux reduction of 89%). CONCLUSIONS: A large field-of-view SPCCT prototype demonstrates HR technical capabilities and high image quality for high resolution lung CT in human.
PURPOSE: The purpose of this study was to characterize the technical capabilities and feasibility of a large field-of-view clinical spectral photon-counting computed tomography (SPCCT) prototype for high-resolution (HR) lung imaging. MATERIALS AND METHODS: Measurement of modulation transfer function (MTF) and acquisition of a line pairs phantom were performed. An anthropomorphic lung nodule phantom was scanned with standard (120kVp, 62mAs), low (120kVp, 11mAs), and ultra-low (80kVp, 3mAs) radiation doses. A human volunteer underwent standard (120kVp, 63mAs) and low (120kVp, 11mAs) dose scans after approval by the ethics committee. HR images were reconstructed with 1024 matrix, 300mm field of view and 0.25mm slice thickness using a filtered-back projection (FBP) and two levels of iterative reconstruction (iDose 5 and 9). The conspicuity and sharpness of various lung structures (distal airways, vessels, fissures and proximal bronchial wall), image noise, and overall image quality were independently analyzed by three radiologists and compared to a previous HR lung CT examination of the same volunteer performed with a conventional CT equipped with energy integrating detectors (120kVp, 10mAs, FBP). RESULTS: Ten percent MTF was measured at 22.3lp/cm with a cut-off at 31lp/cm. Up to 28lp/cm were depicted. While mixed and solid nodules were easily depicted on standard and low-dose phantom images, higher iDose levels and slice thicknesses (1mm) were needed to visualize ground-glass components on ultra-low-dose images. Standard dose SPCCT images of in vivo lung structures were of greater conspicuity and sharpness, with greater overall image quality, and similar image noise (despite a flux reduction of 23%) to conventional CT images. Low-dose SPCCT images were of greater or similar conspicuity and sharpness, similar overall image quality, and lower but acceptable image noise (despite a flux reduction of 89%). CONCLUSIONS: A large field-of-view SPCCT prototype demonstrates HR technical capabilities and high image quality for high resolution lung CT in human.
Authors: Kishore Rajendran; Martin Petersilka; André Henning; Elisabeth R Shanblatt; Bernhard Schmidt; Thomas G Flohr; Andrea Ferrero; Francis Baffour; Felix E Diehn; Lifeng Yu; Prabhakar Rajiah; Joel G Fletcher; Shuai Leng; Cynthia H McCollough Journal: Radiology Date: 2021-12-14 Impact factor: 11.105
Authors: Pedro Augusto Gondim Teixeira; Nicolas Villani; Malik Ait Idir; Edouard Germain; Charles Lombard; Romain Gillet; Alain Blum Journal: Quant Imaging Med Surg Date: 2021-10
Authors: Francis I Baffour; Kishore Rajendran; Katrina N Glazebrook; Jamison E Thorne; Nicholas B Larson; Shuai Leng; Cynthia H McCollough; Joel G Fletcher Journal: Eur Radiol Date: 2022-06-11 Impact factor: 7.034
Authors: David C Rotzinger; Damien Racine; Fabio Becce; Elias Lahoud; Klaus Erhard; Salim A Si-Mohamed; Joël Greffier; Anaïs Viry; Loïc Boussel; Reto A Meuli; Yoad Yagil; Pascal Monnin; Philippe C Douek Journal: Diagnostics (Basel) Date: 2021-12-16
Authors: Niels R van der Werf; S Si-Mohamed; P A Rodesch; R W van Hamersvelt; M J W Greuter; S Boccalini; J Greffier; T Leiner; L Boussel; M J Willemink; P Douek Journal: Eur Radiol Date: 2021-07-13 Impact factor: 5.315