Literature DB >> 33609781

Driving success in personalized medicine through AI-enabled computational modeling.

Kaushik Chakravarty1, Victor Antontsev1, Yogesh Bundey1, Jyotika Varshney2.   

Abstract

The development of successful drugs is expensive and time-consuming because of high clinical attrition rates. This is caused partially by the rupture seen in the translatability of the drug from the bench to the clinic in the context of personalized medicine. Artificial intelligence (AI)-driven platforms integrated with mechanistic modeling have become instrumental in accelerating the drug development process by leveraging data ubiquitously across the various phases. AI can counter the deficiencies and ambiguities that arise during the classical drug development process while reducing human intervention and bridging the translational gap in discovering the connections between drugs and diseases.
Copyright © 2021 Elsevier Ltd. All rights reserved.

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Year:  2021        PMID: 33609781     DOI: 10.1016/j.drudis.2021.02.007

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  2 in total

1.  In Silico Development of Combinatorial Therapeutic Approaches Targeting Key Signaling Pathways in Metabolic Syndrome.

Authors:  Maksim Khotimchenko; Nicholas E Brunk; Mark S Hixon; Daniel M Walden; Hypatia Hou; Kaushik Chakravarty; Jyotika Varshney
Journal:  Pharm Res       Date:  2022-03-21       Impact factor: 4.200

Review 2.  Evaluating Translational Methods for Personalized Medicine-A Scoping Review.

Authors:  Vibeke Fosse; Emanuela Oldoni; Chiara Gerardi; Rita Banzi; Maddalena Fratelli; Florence Bietrix; Anton Ussi; Antonio L Andreu; Emmet McCormack
Journal:  J Pers Med       Date:  2022-07-19
  2 in total

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