Rachana Singh1, Mary Houghton2, Patrice Melvin3, Elisha M Wachman4, Hafsatou Diop5, Ronald Iverson4, Alan Picarillo6, Lawrence Rhein7, Munish Gupta2. 1. Tufts Children's Hospital, Boston, MA, USA. rsingh2@tuftsmedicalcenter.org. 2. Beth Israel Deaconness Medical Center, Boston, MA, USA. 3. Children's Hospital Boston, Boston, MA, USA. 4. Boston Medical Center, Boston, MA, USA. 5. Massachusetts Department of Public Health, Boston, MA, USA. 6. Maine Medical Centre, Portland, ME, USA. 7. UMass Memorial Medical Center, Worcester, MA, USA.
Abstract
OBJECTIVE: Identify factors associated with the need for pharmacologic therapy (PT) among opioid exposed newborn (OENs). STUDY DESIGN: Retrospective analysis of a statewide database of OENs from 2017 through 2019. Multivariable mixed-effects logistic regression modeled the association of maternal characteristics, infant characteristics, and family engagement practices on the receipt of PT. RESULTS: Of 2098 OENs, 44.8% required PT for NOWS. Higher odds of PT were associated with in-utero exposure to medication treatment for opioid use disorder (MOUD) and non-prescribed opioids in addition to MOUD; nicotine, benzodiazepines, SSRIs; male; out-born infants and mother's ineligibility to provide breast-milk. Lower odds were associated with increasing birth year, skin-to-skin (STS) care, and rooming-in. CONCLUSION: Male, out-born infants exposed to MOUD with additional non-prescribed opioids, nicotine, benzodiazepines and SSSRIs with mothers ineligible to provide breast-milk were more likely to require PT, while modifiable care practices including STS care, and rooming-in decreased the likelihood of PT.
OBJECTIVE: Identify factors associated with the need for pharmacologic therapy (PT) among opioid exposed newborn (OENs). STUDY DESIGN: Retrospective analysis of a statewide database of OENs from 2017 through 2019. Multivariable mixed-effects logistic regression modeled the association of maternal characteristics, infant characteristics, and family engagement practices on the receipt of PT. RESULTS: Of 2098 OENs, 44.8% required PT for NOWS. Higher odds of PT were associated with in-utero exposure to medication treatment for opioid use disorder (MOUD) and non-prescribed opioids in addition to MOUD; nicotine, benzodiazepines, SSRIs; male; out-born infants and mother's ineligibility to provide breast-milk. Lower odds were associated with increasing birth year, skin-to-skin (STS) care, and rooming-in. CONCLUSION: Male, out-born infants exposed to MOUD with additional non-prescribed opioids, nicotine, benzodiazepines and SSSRIs with mothers ineligible to provide breast-milk were more likely to require PT, while modifiable care practices including STS care, and rooming-in decreased the likelihood of PT.
Authors: Shawana Bibi; Nathan Gaddis; Eric O Johnson; Barry M Lester; Walter Kraft; Rachana Singh; Norma Terrin; Susan Adeniyi-Jones; Jonathan M Davis Journal: Pediatr Res Date: 2022-08-16 Impact factor: 3.953