M Ghalleb1,2, S Seghaier3,4, O Adouni5,4, H Bouaziz3,4, A Bouida3,4, J Ben Hassouna3,4, R Chargui3,4, K Rahal3,4. 1. Surgical Oncology Department, Institute Salah Azaiez of Oncology, Tunis, Tunisia. montaghalleb@gmail.com. 2. Faculté de Médecine de Tunis, Institut Salah Azaiz, Université Tunis el Manar, Boulevard Avril 1938, 1006, Tunis, Tunisia. montaghalleb@gmail.com. 3. Surgical Oncology Department, Institute Salah Azaiez of Oncology, Tunis, Tunisia. 4. Faculté de Médecine de Tunis, Institut Salah Azaiz, Université Tunis el Manar, Boulevard Avril 1938, 1006, Tunis, Tunisia. 5. Immuno-Histo-Cytology Department, Institute Salah Azaiez of Oncology, Tunis, Tunisia.
Abstract
BACKGROUND AND AIM: Breast tuberculosis is a rare disease, even in endemic areas. The diagnosis can be challenging, as it can mimic breast cancer. We aim to report our experience and discuss diagnoses and management modalities. RESULTS: We encountered twelve cases of breast tuberculosis in our institution from 2004 to 2019. The average age of our Caucasian North African patients was 42 years old (22-63). The classic presentation was a breast lump found in half of the cases. On physical examination, we suspected breast carcinoma in seven patients. The average size of the tumors was 39 mm (15-80 mm). Nine patients had a mammogram. In five cases, there was a suspicious breast mass mimicking a malignant tumor with an average size of 33 mm (25-60 mm). A ultrasonography was performed in 6 cases and revealed a suspicious ill-circumscribed nodule in four patients with an average size of 37.5 mm (10-60 mm). Five patients had a lumpectomy, and seven women underwent drainage of the abscess and the biopsy of its hull. The association of epithelioid cell granulomas and caseous necrosis was mandatory for the histological diagnosis of tuberculosis. All of them had an antitubercular therapy. The median period of follow-up was of 43 months (3-156 months). One patient presented with a recurrent abscess of the breast. CONCLUSION: Our study found that clinical examination and radiological imaging were not specific. Positive cultures for Koch bacillus or histological confirmation are mandatory for the diagnosis. A meta-analysis of the existing cases is needed.
BACKGROUND AND AIM: Breast tuberculosis is a rare disease, even in endemic areas. The diagnosis can be challenging, as it can mimic breast cancer. We aim to report our experience and discuss diagnoses and management modalities. RESULTS: We encountered twelve cases of breast tuberculosis in our institution from 2004 to 2019. The average age of our Caucasian North African patients was 42 years old (22-63). The classic presentation was a breast lump found in half of the cases. On physical examination, we suspected breast carcinoma in seven patients. The average size of the tumors was 39 mm (15-80 mm). Nine patients had a mammogram. In five cases, there was a suspicious breast mass mimicking a malignant tumor with an average size of 33 mm (25-60 mm). A ultrasonography was performed in 6 cases and revealed a suspicious ill-circumscribed nodule in four patients with an average size of 37.5 mm (10-60 mm). Five patients had a lumpectomy, and seven women underwent drainage of the abscess and the biopsy of its hull. The association of epithelioid cell granulomas and caseous necrosis was mandatory for the histological diagnosis of tuberculosis. All of them had an antitubercular therapy. The median period of follow-up was of 43 months (3-156 months). One patient presented with a recurrent abscess of the breast. CONCLUSION: Our study found that clinical examination and radiological imaging were not specific. Positive cultures for Koch bacillus or histological confirmation are mandatory for the diagnosis. A meta-analysis of the existing cases is needed.
Entities:
Keywords:
Breast disease; Granulomatosis; Tuberculosis
Authors: C F Longman; T Campion; B Butler; T D Suaris; A Khanam; H Kunst; S Tiberi; S A O'Keeffe Journal: Clin Radiol Date: 2017-01-06 Impact factor: 2.350
Authors: J Ben Hassouna; A Gamoudi; H Bouzaiene; T Dhiab; F Khomsi; R Chargui; H Sifi; M Mtaallah; R Makhlouf; A Chebbi; H Boussen; M Héchiche; K Rahal Journal: Gynecol Obstet Fertil Date: 2005-10-26