Keisuke Sugimoto1, Shinji Uejima2, Yumiko Uchiyama1, Reita Yasue1, Kazuya Nambu1, Jun Ishikawa1, Yoshiro Koma3, Takako Akita4, Taketomo Toh4, Takehiro Fujimoto1. 1. Department of Oral and Maxillofacial Surgery, Iwata City Hospital, Iwata. 2. Department of Oral and Maxillofacial Surgery, Nagoya University Hospital. 3. Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya. 4. Department of Oral and Maxillofacial Surgery, Tokoname City Hospital, 3-3-3 Asukadai, Tokoname, Aichi, Japan.
Abstract
RATIONALE: Oral cancer often causes secondary primary cancers in the upper gastrointestinal tract. However, there are no reports of secondary primary cancers in patients with oral squamous cell carcinoma and malignant lymphoma of the small intestine. This report describes a case of metachronous multiple primary cancers of the tongue and small intestine malignant lymphoma. PATIENTS CONCERNS: The patient was admitted to our department with the chief complaint of pain in the right tongue. Partial tongue resection and supraomohyoid neck dissection were performed. One year after surgery, the patient experienced abdominal pain and bloody stools. DIAGNOSIS: Diffuse large B-cell lymphoma (DLBCL) was diagnosed via histological examination. INTERVENTIONS: A terminal ileum resection was performed. Postoperatively, the patient received 6 courses of rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP). OUTCOMES: Five years after his initial diagnosis, there is no evidence of recurrence, metastasis, or other primary cancer. LESSONS: Oral cancer patients should always be followed up owing to a possibility of malignant tumors in other areas.
RATIONALE: Oral cancer often causes secondary primary cancers in the upper gastrointestinal tract. However, there are no reports of secondary primary cancers in patients with oral squamous cell carcinoma and malignant lymphoma of the small intestine. This report describes a case of metachronous multiple primary cancers of the tongue and small intestine malignant lymphoma. PATIENTS CONCERNS: The patient was admitted to our department with the chief complaint of pain in the right tongue. Partial tongue resection and supraomohyoid neck dissection were performed. One year after surgery, the patient experienced abdominal pain and bloody stools. DIAGNOSIS: Diffuse large B-cell lymphoma (DLBCL) was diagnosed via histological examination. INTERVENTIONS: A terminal ileum resection was performed. Postoperatively, the patient received 6 courses of rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP). OUTCOMES: Five years after his initial diagnosis, there is no evidence of recurrence, metastasis, or other primary cancer. LESSONS: Oral cancer patients should always be followed up owing to a possibility of malignant tumors in other areas.
Authors: Ho Sup Lee; Lee Chun Park; Eun Mi Lee; Seong Hoon Shin; Byeong Jin Ye; Sung Yong Oh; Moo Kon Song; Sang Min Lee; Won Sik Lee; Byung Woog Kang; Myung Hee Chang; Seok-Goo Cho; Seung Ah Yahng; Sung-Soo Yoon; Ji-Hyun Kwon; Yang Soo Kim Journal: Am J Clin Oncol Date: 2014-04 Impact factor: 2.339
Authors: Michael C R Alavanja; Jonathan N Hofmann; Charles F Lynch; Cynthia J Hines; Kathryn H Barry; Joseph Barker; Dennis W Buckman; Kent Thomas; Dale P Sandler; Jane A Hoppin; Stella Koutros; Gabriella Andreotti; Jay H Lubin; Aaron Blair; Laura E Beane Freeman Journal: PLoS One Date: 2014-10-22 Impact factor: 3.240