Literature DB >> 33607003

Shining a Light on Phenotypic Drug Discovery.

Ku-Lung Hsu1.   

Abstract

In this issue of Cell Chemical Biology, Seneviratne et al. (2020) combine photoaffinity labeling and quantitative chemical proteomics to identify the molecular target of a lead compound discovered from a phenotypic drug screen. Their work showcase the power of coupling a photoreactive group to screening hits for rapid target deconvolution.
Copyright © 2021 Elsevier Ltd. All rights reserved.

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Year:  2021        PMID： 33607003      PMCID： PMC8121186          DOI： 10.1016/j.chembiol.2021.01.020

Source DB:  PubMed          Journal:  Cell Chem Biol        ISSN： 2451-9448            Impact factor:   8.116


  10 in total

1.  Fully functionalized small-molecule probes for integrated phenotypic screening and target identification.

Authors:  Justin S Cisar; Benjamin F Cravatt
Journal:  J Am Chem Soc       Date:  2012-06-13       Impact factor: 15.419

Review 2.  How many drug targets are there?

Authors:  John P Overington; Bissan Al-Lazikani; Andrew L Hopkins
Journal:  Nat Rev Drug Discov       Date:  2006-12       Impact factor: 84.694

Review 3.  How were new medicines discovered?

Authors:  David C Swinney; Jason Anthony
Journal:  Nat Rev Drug Discov       Date:  2011-06-24       Impact factor: 84.694

Review 4.  Opportunities and challenges in phenotypic drug discovery: an industry perspective.

Authors:  John G Moffat; Fabien Vincent; Jonathan A Lee; Jörg Eder; Marco Prunotto
Journal:  Nat Rev Drug Discov       Date:  2017-07-07       Impact factor: 84.694

5.  Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE.

Authors:  Uthpala Seneviratne; Zhen Huang; Christopher W Am Ende; Todd W Butler; Leah Cleary; Erica Dresselhaus; Edelweiss Evrard; Ethan L Fisher; Michael E Green; Christopher J Helal; John M Humphrey; Lorraine F Lanyon; Michael Marconi; Paramita Mukherjee; Simone Sciabola; Claire M Steppan; Emily K Sylvain; Jamison B Tuttle; Patrick R Verhoest; Travis T Wager; Longfei Xie; Gayathri Ramaswamy; Douglas S Johnson; Martin Pettersson
Journal:  Cell Chem Biol       Date:  2020-09-29       Impact factor: 8.116

Review 6.  The Life of Pi Star: Exploring the Exciting and Forbidden Worlds of the Benzophenone Photophore.

Authors:  György Dormán; Hiroyuki Nakamura; Abigail Pulsipher; Glenn D Prestwich
Journal:  Chem Rev       Date:  2016-12-16       Impact factor: 60.622

7.  Ligand and Target Discovery by Fragment-Based Screening in Human Cells.

Authors:  Christopher G Parker; Andrea Galmozzi; Yujia Wang; Bruno E Correia; Kenji Sasaki; Christopher M Joslyn; Arthur S Kim; Cullen L Cavallaro; R Michael Lawrence; Stephen R Johnson; Iñigo Narvaiza; Enrique Saez; Benjamin F Cravatt
Journal:  Cell       Date:  2017-01-19       Impact factor: 41.582

8.  Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

Authors:  Suzanne E Wahrle; Hong Jiang; Maia Parsadanian; Jungsu Kim; Aimin Li; Amanda Knoten; Sanjay Jain; Veronica Hirsch-Reinshagen; Cheryl L Wellington; Kelly R Bales; Steven M Paul; David M Holtzman
Journal:  J Clin Invest       Date:  2008-02       Impact factor: 14.808

9.  Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease.

Authors:  Eric M Reiman; Kewei Chen; Xiaofen Liu; Daniel Bandy; Meixiang Yu; Wendy Lee; Napatkamon Ayutyanont; Jennifer Keppler; Stephanie A Reeder; Jessica B S Langbaum; Gene E Alexander; William E Klunk; Chester A Mathis; Julie C Price; Howard J Aizenstein; Steven T DeKosky; Richard J Caselli
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-03       Impact factor: 11.205

Review 10.  The role of apolipoprotein E in Alzheimer's disease.

Authors:  Jungsu Kim; Jacob M Basak; David M Holtzman
Journal:  Neuron       Date:  2009-08-13       Impact factor: 17.173
  10 in total

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