| Literature DB >> 33605839 |
Volker Vetter1,2, Robert C Gardner1,2, Serge Debrus1,2, Bernd Benninghoff1,2, Priya Pereira1,2.
Abstract
Robust scientific evidence related to two rotavirus (RV) vaccines available worldwide demonstrates their significant impact on RV disease burden. Improving RV vaccination coverage may result in better RV disease control. To make RV vaccination accessible to all eligible children worldwide and improve vaccine effectiveness in high-mortality settings, research into new RV vaccines continues. Although current and in-development RV vaccines differ in vaccine design, their common goal is the reduction of RV disease risk in children <5 years old for whom disease burden is the most significant. Given the range of RV vaccines available, informed decision-making is essential regarding the choice of vaccine for immunization. This review aims to describe the landscape of current and new RV vaccines, providing context for the assessment of their similarities and differences. As data for new vaccines are limited, future investigations will be required to evaluate their performance/added value in a real-world setting.Entities:
Keywords: Rotavirus vaccines; coverage; impact; rotavirus vaccine design
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Year: 2021 PMID： 33605839 PMCID： PMC8920198 DOI： 10.1080/21645515.2020.1870395
Source DB: PubMed Journal: Hum Vaccin Immunother ISSN： 2164-5515 Impact factor: 3.452