Literature DB >> 33604093

Chronic Immune Thrombocytopenia and Hashimoto's Hypothyroidism in an Adolescent: Presentation and Implications.

Judy Ibrahim1, Mohammad Alashqar1, Shamma Al Zaabi1, Omar Trad2, Amar Al Shibli3.   

Abstract

Immune thrombocytopenia (ITP) is a disorder characterized by immune-mediated destruction of thrombocytes leading to peripheral blood platelet count of <100 × 10^9/L. Primary ITP is a terminology used in the absence of other causes or disorders that may be associated with thrombocytopenia, i.e., isolated thrombocytopenia. The term secondary ITP is used if such diseases coexist. We present here a case of a 14-year-old female diagnosed with immune thrombocytopenia. When her evaluation was not strongly supportive of primary ITP, she was screened and proved to have a concomitant Hashimoto thyroiditis. Contrary to the popular belief about secondary ITP in adult population, treatment of our patient's hypothyroidism did not improve her platelet's count, and the patient needed multiple immunosuppressive medications to improve her condition.
Copyright © 2021 Judy Ibrahim et al.

Entities:  

Year:  2021        PMID: 33604093      PMCID: PMC7872745          DOI: 10.1155/2021/6649155

Source DB:  PubMed          Journal:  Case Rep Pediatr


  13 in total

1.  Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group.

Authors:  Francesco Rodeghiero; Roberto Stasi; Terry Gernsheimer; Marc Michel; Drew Provan; Donald M Arnold; James B Bussel; Douglas B Cines; Beng H Chong; Nichola Cooper; Bertrand Godeau; Klaus Lechner; Maria Gabriella Mazzucconi; Robert McMillan; Miguel A Sanz; Paul Imbach; Victor Blanchette; Thomas Kühne; Marco Ruggeri; James N George
Journal:  Blood       Date:  2008-11-12       Impact factor: 22.113

2.  Prevalence of elevated antithyroid antibodies and antinuclear antibodies in children with immune thrombocytopenic purpura.

Authors:  Ellen L Pratt; Michael D Tarantino; Debra Wagner; Ora Hirsch Pescovitz; Suzanne Bowyer; Amy D Shapiro
Journal:  Am J Hematol       Date:  2005-07       Impact factor: 10.047

Review 3.  The incidence of immune thrombocytopenic purpura in children and adults: A critical review of published reports.

Authors:  Deirdra R Terrell; Laura A Beebe; Sara K Vesely; Barbara R Neas; Jodi B Segal; James N George
Journal:  Am J Hematol       Date:  2010-03       Impact factor: 10.047

4.  Role of antithyroid autoimmunity as a predictive biomarker of chronic immune thrombocytopenia.

Authors:  Paola Giordano; Flavia Urbano; Giuseppe Lassandro; Francesco Paolo Bianchi; Alessandra Tolva; Paola Saracco; Giovanna Russo; Lucia Dora Notarangelo; Maria Gabelli; Simone Cesaro; Malgorzata Wasniewska; Maria Felicia Faienza
Journal:  Pediatr Blood Cancer       Date:  2018-09-30       Impact factor: 3.167

5.  Resolution of chronic severe refractory thrombocytopenia after treatment of hypothyroidism.

Authors:  K M Bowles; G E Turner; J Z Wimperis
Journal:  J Clin Pathol       Date:  2004-09       Impact factor: 3.411

Review 6.  Thyroid disease in patients with immune thrombocytopenia.

Authors:  Eric Cheung; Howard A Liebman
Journal:  Hematol Oncol Clin North Am       Date:  2009-12       Impact factor: 3.722

7.  Prevalence and clinical significance of antithyroid antibodies in children with immune thrombocytopenic purpura.

Authors:  Ali Bay; Enes Coskun; Goksel Leblebisatan; Ozlem Karaoglu; Mehmet Keskin; Sibel Yavuz; Fatih Yilmaz; Alper Dai; Mehmet Yavuz Coskun
Journal:  Pediatr Hematol Oncol       Date:  2013-01-09       Impact factor: 1.969

8.  Role of the T and B lymphocytes in pathogenesis of autoimmune thyroid diseases.

Authors:  Marta Rydzewska; Michał Jaromin; Izabela Elżbieta Pasierowska; Karlina Stożek; Artur Bossowski
Journal:  Thyroid Res       Date:  2018-02-13

9.  Immune Thrombocytopenia (ITP) Secondary to Subclinical Hashimoto's Thyroiditis: Role of Levothyroxine in Improving the Clinical Outcome of ITP.

Authors:  Hassan Tahir; Faizan Sheraz; Jahnavi Sagi; Vistasp Daruwalla
Journal:  J Investig Med High Impact Case Rep       Date:  2016-05-02

10.  Regulatory and Memory B Lymphocytes in Children With Newly Diagnosed Immune Thrombocytopenia.

Authors:  Asmaa M Zahran; Sanaa Shaker Aly; Ahmed Elabd; Ismail Lotfy Mohamad; Khalid I Elsayh
Journal:  J Hematol       Date:  2017-09-20
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