BACKGROUND: We investigated changes in bone metabolism markers over time for evaluating the effect of denosumab following administration to patients with spinal metastasis. METHODS: Subjects of this study were 28 patients treated at the Department of Orthopedic Surgery at Aichi Medical University. RESULTS: At 6 months after denosumab intervention, measured TRAP-5b values were significantly lower compared to pre-intervention values in both the osteosclerotic lesion and osteolytic lesion groups. CONCLUSIONS: This change in bone metabolism marker values over time is one of the methods for evaluating the effect of treatment on bone tissue in cases of spinal metastasis.
BACKGROUND: We investigated changes in bone metabolism markers over time for evaluating the effect of denosumab following administration to patients with spinal metastasis. METHODS: Subjects of this study were 28 patients treated at the Department of Orthopedic Surgery at Aichi Medical University. RESULTS: At 6 months after denosumab intervention, measured TRAP-5b values were significantly lower compared to pre-intervention values in both the osteosclerotic lesion and osteolytic lesion groups. CONCLUSIONS: This change in bone metabolism marker values over time is one of the methods for evaluating the effect of treatment on bone tissue in cases of spinal metastasis.
Authors: A Berruti; L Dogliotti; R Bitossi; G Fasolis; G Gorzegno; M Bellina; M Torta; F Porpiglia; D Fontana; A Angeli Journal: J Urol Date: 2000-10 Impact factor: 7.450
Authors: Matthew R Smith; Fred Saad; Robert Coleman; Neal Shore; Karim Fizazi; Bertrand Tombal; Kurt Miller; Paul Sieber; Lawrence Karsh; Ronaldo Damião; Teuvo L Tammela; Blair Egerdie; Hendrik Van Poppel; Joseph Chin; Juan Morote; Francisco Gómez-Veiga; Tomasz Borkowski; Zhishen Ye; Amy Kupic; Roger Dansey; Carsten Goessl Journal: Lancet Date: 2011-11-15 Impact factor: 79.321
Authors: Quirina C B S Thio; Nuno Rui Paulino Pereira; Olivier van Wulfften Palthe; Daniel M Sciubba; Jos A M Bramer; Joseph H Schwab Journal: J Orthop Date: 2021-11-27