| Literature DB >> 33602968 |
Astros Th Skuladottir1, Gyda Bjornsdottir2, Gudmar Thorleifsson2, G Bragi Walters2,3, Muhammad Sulaman Nawaz2,3, Kristjan Helgi Swerford Moore2, Pall I Olason2, Thorgeir E Thorgeirsson2, Brynja Sigurpalsdottir2,4, Gardar Sveinbjornsson2, Hannes P Eggertsson2, Sigurdur H Magnusson2, Asmundur Oddsson2, Anna Bjornsdottir5, Arnor Vikingsson6, Olafur A Sveinsson6, Maria G Hrafnsdottir6, Gudrun R Sigurdardottir5, Bjarni V Halldorsson2, Thomas Folkmann Hansen7, Helene Paarup8, Christian Erikstrup9, Kaspar Nielsen10, Mads Klokker11, Mie Topholm Bruun8, Erik Sorensen11, Karina Banasik7, Kristoffer S Burgdorf11, Ole Birger Pedersen12, Henrik Ullum11, Ingileif Jonsdottir2,3, Hreinn Stefansson2, Kari Stefansson2,3.
Abstract
Bell's palsy is the most common cause of unilateral facial paralysis and is defined as an idiopathic and acute inability to control movements of the facial muscles on the affected side. While the pathogenesis remains unknown, previous studies have implicated post-viral inflammation and resulting compression of the facial nerve. Reported heritability estimates of 4-14% suggest a genetic component in the etiology and an autosomal dominant inheritance has been proposed. Here, we report findings from a meta-analysis of genome-wide association studies uncovering the first unequivocal association with Bell's palsy (rs9357446-A; P = 6.79 × 10-23, OR = 1.23; Ncases = 4714, Ncontrols = 1,011,520). The variant also confers risk of intervertebral disc disorders (P = 2.99 × 10-11, OR = 1.04) suggesting a common pathogenesis in part or a true pleiotropy.Entities:
Mesh：
Year: 2021 PMID： 33602968 PMCID： PMC7893061 DOI： 10.1038/s41598-021-82736-w
Source DB: PubMed Journal: Sci Rep ISSN： 2045-2322 Impact factor: 4.379