| Literature DB >> 33602609 |
Niels G A Willemen1, Shabir Hassan2, Melvin Gurian3, Jinghang Li4, Iris E Allijn3, Su Ryon Shin5, Jeroen Leijten6.
Abstract
Oxygen is essential for the survival, function, and fate of mammalian cells. Oxygen tension controls cellular behaviour via metabolic programming, which in turn controls tissue regeneration, stem cell differentiation, drug metabolism, and numerous pathologies. Thus, oxygen-releasing biomaterials represent a novel and unique strategy to gain control over a variety of in vivo processes. Consequently, numerous oxygen-generating or carrying materials have been developed in recent years, which offer innovative solutions in the field of drug efficiency, regenerative medicine, and engineered living systems. In this review, we discuss the latest trends, highlight current challenges and solutions, and provide a future perspective on the field of oxygen-releasing materials.Entities:
Keywords: biomaterials; hypoxia; metabolism; oxygen generation; sustained release
Mesh:
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Year: 2021 PMID: 33602609 PMCID: PMC9078202 DOI: 10.1016/j.tibtech.2021.01.007
Source DB: PubMed Journal: Trends Biotechnol ISSN: 0167-7799 Impact factor: 21.942