Cecilia Fernández-Ponce1, Roberto Navarro Quiroz2, Anderson Díaz Perez3,4, Gustavo Aroca Martinez3,5, Andrés Cadena Bonfanti3,5, Antonio Acosta Hoyos3, Lorena Gómez Escorcia3,4, Sandra Hernández Agudelo3,5, Christian Orozco Sánchez3, José Villarreal Camacho6, Linda Atencio Ibarra7, Jose Consuegra Machado7, Alberto Espinoza Garavito3, Francisco García-Cózar1, Elkin Navarro Quiroz8,9. 1. Department of Biomedicine, Biotechnology and Public Health, University of Cadiz, Cadiz, Spain. 2. CMCC-Centro de Matemática, Computação E Cognição, Laboratório do Biología Computacional e Bioinformática-LBCB, Universidade Federal Do ABC, Sao Paulo, 01023, Brazil. 3. Facultad de Ciencias Básicas y Biomédicas, Universidad Simon Bolivar, 080001, Barranquilla, Colombia. 4. Universidad Rafael Nuñez, 130001, Cartagena, Colombia. 5. Department of Nephrology, Clinica de La Costa, 080001, Barranquilla, Colombia. 6. School of Medicine, Universidad Libre, 080001, Barranquilla, Colombia. 7. School of Medicine, Universidad Simon Bolivar, 080001, Barranquilla, Colombia. 8. Facultad de Ciencias Básicas y Biomédicas, Universidad Simon Bolivar, 080001, Barranquilla, Colombia. enavarro26@unisimonbolivar.edu.co. 9. Centro de Investigación E Innovación en Biomoléculas, C4U S.A.S, 080001, Barranquilla, Colombia. enavarro26@unisimonbolivar.edu.co.
Abstract
BACKGROUND: In this review, we were interested to identify the wide universe of enzymes associated with epigenetic modifications, whose gene expression is regulated by miRNAs with a high relative abundance in Crohn's disease (CD) affected tissues, with the aim to determine their impact in the pathogenesis and evolution of the disease. METHODS: We used HMDD and Bibliometrix R-package in order to identify the miRNAs overexpressed in CD. The identified enzymes associated with epigenetic mechanisms and post-translational modifications, regulated by miRNAs upregulated in CD, were analyzed using String v11 database. RESULTS: We found 190 miRNAs with great abundance in patients with CD, of which 26 miRNAs regulate the gene expression of enzymes known to catalyze epigenetic modifications involved in essentials pathophysiological processes, such as chromatin architecture reorganization, immune response regulation including CD4+ T cells polarization, integrity of gut mucosa, gut microbiota composition and tumorigenesis. CONCLUSION: The integrated analysis of miRNAs with a high relative abundance in patients with CD showed a combined and superimposed gene expression regulation of enzymes associated with relevant epigenetic mechanisms and that could explain, in part, the pathogenesis of CD.
BACKGROUND: In this review, we were interested to identify the wide universe of enzymes associated with epigenetic modifications, whose gene expression is regulated by miRNAs with a high relative abundance in Crohn's disease (CD) affected tissues, with the aim to determine their impact in the pathogenesis and evolution of the disease. METHODS: We used HMDD and Bibliometrix R-package in order to identify the miRNAs overexpressed in CD. The identified enzymes associated with epigenetic mechanisms and post-translational modifications, regulated by miRNAs upregulated in CD, were analyzed using String v11 database. RESULTS: We found 190 miRNAs with great abundance in patients with CD, of which 26 miRNAs regulate the gene expression of enzymes known to catalyze epigenetic modifications involved in essentials pathophysiological processes, such as chromatin architecture reorganization, immune response regulation including CD4+ T cells polarization, integrity of gut mucosa, gut microbiota composition and tumorigenesis. CONCLUSION: The integrated analysis of miRNAs with a high relative abundance in patients with CD showed a combined and superimposed gene expression regulation of enzymes associated with relevant epigenetic mechanisms and that could explain, in part, the pathogenesis of CD.
Entities:
Keywords:
Crohn’s disease; Epigenetic mechanisms; MicroRNA; Post-translational modifications; T cells
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