Samantha Pegg1, Kodi B Arfer2, Autumn Kujawa3. 1. Vanderbilt University, Department of Psychology and Human Development, United States. 2. Mount Sinai Health System, Icahn School of Medicine, Department of Environmental Medicine and Public Health, United States. 3. Vanderbilt University, Department of Psychology and Human Development, United States. Electronic address: autumn.kujawa@vanderbilt.edu.
Abstract
BACKGROUND: Alterations in positive valence systems and social processes, including low reward responsiveness and high rejection sensitivity, have been observed in depression. Most reward research focuses on the monetary domain, but social reward responsiveness may be particularly relevant to understanding the etiology of depression, especially in combination with other social processes. Pathways to depression are complex, and research testing interactions between multiple factors is needed. The present study examined the interactive effects of reward responsiveness and rejection sensitivity on depressive symptoms using both social and monetary reward electroencephalogram (EEG) tasks. METHODS: Emerging adults (N = 120) completed peer interaction and monetary incentive delay tasks while EEG data were recorded, as well as self-report measures of rejection sensitivity and depressive symptoms. RESULTS: The interaction between social reward responsiveness and self-reported rejection sensitivity was significantly associated with depressive symptoms, such that rejection sensitivity was associated with greater depressive symptoms for those with a relatively reduced response to social reward. The interaction between monetary reward responsiveness and rejection sensitivity was not significant. LIMITATIONS: The study was cross-sectional and used a non-clinical sample. CONCLUSIONS: Results suggest a possible pathway for depressive symptoms characterized by the combination of high rejection sensitivity and low social reward responsiveness. Findings highlight the need for consideration of multiple domains of reward responsiveness in clinical neuroscience research. With extension to longitudinal studies and clinical samples, the present findings may inform understanding of targets for intervention.
BACKGROUND: Alterations in positive valence systems and social processes, including low reward responsiveness and high rejection sensitivity, have been observed in depression. Most reward research focuses on the monetary domain, but social reward responsiveness may be particularly relevant to understanding the etiology of depression, especially in combination with other social processes. Pathways to depression are complex, and research testing interactions between multiple factors is needed. The present study examined the interactive effects of reward responsiveness and rejection sensitivity on depressive symptoms using both social and monetary reward electroencephalogram (EEG) tasks. METHODS: Emerging adults (N = 120) completed peer interaction and monetary incentive delay tasks while EEG data were recorded, as well as self-report measures of rejection sensitivity and depressive symptoms. RESULTS: The interaction between social reward responsiveness and self-reported rejection sensitivity was significantly associated with depressive symptoms, such that rejection sensitivity was associated with greater depressive symptoms for those with a relatively reduced response to social reward. The interaction between monetary reward responsiveness and rejection sensitivity was not significant. LIMITATIONS: The study was cross-sectional and used a non-clinical sample. CONCLUSIONS: Results suggest a possible pathway for depressive symptoms characterized by the combination of high rejection sensitivity and low social reward responsiveness. Findings highlight the need for consideration of multiple domains of reward responsiveness in clinical neuroscience research. With extension to longitudinal studies and clinical samples, the present findings may inform understanding of targets for intervention.
Authors: Brandon L Goldstein; Ellen M Kessel; Autumn Kujawa; Megan C Finsaas; Joanne Davila; Greg Hajcak; Daniel N Klein Journal: Psychol Med Date: 2019-07-05 Impact factor: 7.723
Authors: Kathryn R Hill; David T Hsu; Stephan F Taylor; R Todd Ogden; Christine DeLorenzo; Ramin V Parsey Journal: Psychiatry Res Neuroimaging Date: 2022-06-06 Impact factor: 2.493