Shizuka Sakuta1, Mamoru Hashimoto2,3, Manabu Ikeda3, Asuka Koyama2, Akihiro Takasaki1,4, Maki Hotta1,5, Ryuji Fukuhara4, Tomohisa Ishikawa4, Seiji Yuki4, Yusuke Miyagawa4, Yosuke Hidaka1, Keiichiro Kaneda6, Minoru Takebayashi2,7. 1. Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. 2. Faculty of Life Sciences, Department of Neuropsychiatry, Kumamoto University, Kumamoto, Japan. 3. Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. 4. Department of Neuropsychiatry, Kumamoto University Hospital, Kumamoto, Japan. 5. Department of Behavioral Neurology and Neuropsychiatry, Osaka University United Graduate School of Child Development, Suita, Osaka, Japan. 6. Kumamoto Seimei Hospital, Kumamoto, Japan. 7. Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan.
Abstract
OBJECTIVE: To investigate the behavioral characteristics of semantic dementia (SD) using an instrument originally developed for patients with autism spectrum disorder. METHODS: The behavioral symptoms of 20 patients with SD and 20 patients with Alzheimer's disease (AD) in both the preclinical state and the dementia state were evaluated using the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS). RESULTS: The SD group showed high prevalence in four behaviors related to stereotypy and social impairment: eating very few food items, selfishness, difficulty in recognizing others' feeling and thoughts, and interpreting language literally. Scores on the PARS short version, which is sensitive for diagnosis of autism spectrum disorder, were significantly higher in the dementia state than in the preclinical state in both the SD (11.5 ± 6.0 and 1.7 ± 2.5, respectively; t (19) = 6.7, p < 0.001) and AD (6.9 ± 4.6 and 1.7 ± 2.0, respectively; t (19) = 5.1, p < 0.001) groups. PARS short version scores after dementia onset increased in both the SD and AD groups, although the increase was significantly larger in the SD group (F = 5.6, p = 0.023). Additionally, a significantly higher rate of patients exceeded the cutoff score for autism diagnosis in the dementia state in the SD group (75%) than in the AD group (40%; χ2 = 5.0, p = 0.025). PARS scores in the dementia state were significantly correlated with illness duration (r = 0.46, p = 0.04) and Mini-Mental State Examination scores (r = -0.75, p < 0.001) in the SD group only. CONCLUSIONS: Although SD and autism spectrum disorder are etiologically distinct diseases, patients with semantic dementia behave like those with autism spectrum disorder. Our findings suggest the symptomatic similarity of the two disorders.
OBJECTIVE: To investigate the behavioral characteristics of semantic dementia (SD) using an instrument originally developed for patients with autism spectrum disorder. METHODS: The behavioral symptoms of 20 patients with SD and 20 patients with Alzheimer's disease (AD) in both the preclinical state and the dementia state were evaluated using the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS). RESULTS: The SD group showed high prevalence in four behaviors related to stereotypy and social impairment: eating very few food items, selfishness, difficulty in recognizing others' feeling and thoughts, and interpreting language literally. Scores on the PARS short version, which is sensitive for diagnosis of autism spectrum disorder, were significantly higher in the dementia state than in the preclinical state in both the SD (11.5 ± 6.0 and 1.7 ± 2.5, respectively; t (19) = 6.7, p < 0.001) and AD (6.9 ± 4.6 and 1.7 ± 2.0, respectively; t (19) = 5.1, p < 0.001) groups. PARS short version scores after dementia onset increased in both the SD and AD groups, although the increase was significantly larger in the SD group (F = 5.6, p = 0.023). Additionally, a significantly higher rate of patients exceeded the cutoff score for autism diagnosis in the dementia state in the SD group (75%) than in the AD group (40%; χ2 = 5.0, p = 0.025). PARS scores in the dementia state were significantly correlated with illness duration (r = 0.46, p = 0.04) and Mini-Mental State Examination scores (r = -0.75, p < 0.001) in the SD group only. CONCLUSIONS: Although SD and autism spectrum disorder are etiologically distinct diseases, patients with semantic dementia behave like those with autism spectrum disorder. Our findings suggest the symptomatic similarity of the two disorders.
Authors: Jessica A Collins; Victor Montal; Daisy Hochberg; Megan Quimby; Maria Luisa Mandelli; Nikos Makris; William W Seeley; Maria Luisa Gorno-Tempini; Bradford C Dickerson Journal: Brain Date: 2016-12-31 Impact factor: 13.501
Authors: H J Rosen; S C Allison; J M Ogar; S Amici; K Rose; N Dronkers; B L Miller; M L Gorno-Tempini Journal: Neurology Date: 2006-11-28 Impact factor: 9.910
Authors: Alessandra M Pereira; Brunno M Campos; Ana C Coan; Luiz F Pegoraro; Thiago J R de Rezende; Ignacio Obeso; Paulo Dalgalarrondo; Jaderson C da Costa; Jean-Claude Dreher; Fernando Cendes Journal: Front Neurol Date: 2018-07-10 Impact factor: 4.003