| Literature DB >> 335997 |
Abstract
Suloctidil (0.5 to 5.0 micrometer) inhibits insulin release evoked by glucose or alpha-ketoisocaproate in pancreatic islets. The drug also inhibits basal and glucose-stimulated 45calcium net uptake by the islets. In an artificial system, suloctidil inhibits A23187-mediated calcium translocation. It is proposed that the inhibitory action of suloctidil upon islet function may be due to interference with B-cell native ionophoretic system(s).Entities:
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Year: 1977 PMID： 335997
Source DB: PubMed Journal: Arch Int Pharmacodyn Ther ISSN： 0003-9780