Jose Fernandez-Ferro1, Lee H Schwamm2, Patrick D Lyden3, Kennedy R Lees4. 1. Stroke Unit, Department of Neurology, Hospital Universitario Rey Juan Carlos, Instituto de Investigacion Sanitaria - Hospital Universitario Fundación Jiménez Díaz Universidad Autonóma de Madrid, Madrid, Spain. 2. Department of Neurology, Comprehensive Stroke, Massachusetts General Hospital Center, Harvard Medical School, Boston, MA, USA. 3. Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 4. Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.