Suleyman Eserdag1, Didem Kurban2, Mine Kiseli3, Murat Alan4, Yasemin Alan5. 1. Hera Clinic, Istanbul, Turkey. 2. Hera Clinic, Ankara, Turkey. 3. Faculty of Medicine, Ufuk University, Ankara, Turkey. 4. Tepecik Educational and Research Hospital, Kazim Dirik District, 35100 Bornova, Izmir, Turkey. 5. Izmir Metropolitan Municipality Esrefpasa Hospital, Izmir, Turkey.
Abstract
INTRODUCTION: Localized Provoked Vulvodynia (LPV) is a gynecological disease that is difficult to manage. Despite the wide spectrum of pathophysiological mechanisms and treatment modalities, there is limited success in the management of this disease. Surgical treatment is usually performed as the last resort. We aimed to investigate the histopathological results of 38 women with LPV who underwent surgical vestibulectomy. METHODS: of the 55 women that were diagnosed with LPV and underwent vulvar vestibulectomy, 38 patients with complete histopathological results were included in this retrospective study. RESULTS: in 14 patients, the pathological reports revealed Low-Grade Squamous Intraepithelial Lesions (LGSIL) (36.8%) whereas for 21 cases (55.2%), the findings were concordant with vestibulitis. The remaining three patients (7.8%) were diagnosed with lichen simplex chronicus. CONCLUSION: the presence of LGSIL in the surgical specimens of LPV cases is noteworthy. In this group of patients, surgical excision may contribute to the prevention of progression into high-grade lesions. The relationship between Human Papilloma Virus (HPV) infections and LPV should be further investigated. Copyright: Suleyman Eserdag et al.
INTRODUCTION: Localized Provoked Vulvodynia (LPV) is a gynecological disease that is difficult to manage. Despite the wide spectrum of pathophysiological mechanisms and treatment modalities, there is limited success in the management of this disease. Surgical treatment is usually performed as the last resort. We aimed to investigate the histopathological results of 38 women with LPV who underwent surgical vestibulectomy. METHODS: of the 55 women that were diagnosed with LPV and underwent vulvar vestibulectomy, 38 patients with complete histopathological results were included in this retrospective study. RESULTS: in 14 patients, the pathological reports revealed Low-Grade Squamous Intraepithelial Lesions (LGSIL) (36.8%) whereas for 21 cases (55.2%), the findings were concordant with vestibulitis. The remaining three patients (7.8%) were diagnosed with lichen simplex chronicus. CONCLUSION: the presence of LGSIL in the surgical specimens of LPV cases is noteworthy. In this group of patients, surgical excision may contribute to the prevention of progression into high-grade lesions. The relationship between Human Papilloma Virus (HPV) infections and LPV should be further investigated. Copyright: Suleyman Eserdag et al.
Authors: Gloria A Bachmann; Raymond Rosen; Vivian W Pinn; Wulf H Utian; Charletta Ayers; Rosemary Basson; Yitzchak M Binik; Candace Brown; David C Foster; John M Gibbons; Irwin Goldstein; Alessandra Graziottin; Hope K Haefner; Bernard L Harlow; Susan Kellogg Spadt; Sandra R Leiblum; Robin M Masheb; Barbara D Reed; Jack D Sobel; Christin Veasley; Ursula Wesselmann; Steven S Witkin Journal: J Reprod Med Date: 2006-06 Impact factor: 0.142
Authors: Caroline F Pukall; Andrew T Goldstein; Sophie Bergeron; David Foster; Amy Stein; Susan Kellogg-Spadt; Gloria Bachmann Journal: J Sex Med Date: 2016-03 Impact factor: 3.802
Authors: Jacob Bornstein; Fabrizio Bogliatto; Hope K Haefner; Colleen K Stockdale; Mario Preti; Tanja G Bohl; Jason Reutter Journal: Obstet Gynecol Date: 2016-02 Impact factor: 7.661
Authors: Maria Vadala; Christian Testa; Laura Coda; Stefania Angioletti; Rosanna Giuberti; Carmen Laurino; Beniamino Palmieri Journal: J Clin Med Res Date: 2018-07-31