| Literature DB >> 33597531 |
Shidan Tosif1,2,3, Richard Saffery1,2, Melanie R Neeland4,5, Samantha Bannister1,2,6, Vanessa Clifford1,2,7, Kate Dohle2, Kim Mulholland1,2, Philip Sutton1,2, Nigel Curtis1,2,6, Andrew C Steer1,2,6, David P Burgner1,2,6, Nigel W Crawford1,2,3.
Abstract
Children have mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confirmed disease (COVID-19) compared to adults and the immunological mechanisms underlying this difference remain unclear. Here, we report acute and convalescent innate immune responses in 48 children and 70 adults infected with, or exposed to, SARS-CoV-2. We find clinically mild SARS-CoV-2 infection in children is characterised by reduced circulating subsets of monocytes (classical, intermediate, non-classical), dendritic cells and natural killer cells during the acute phase. In contrast, SARS-CoV-2-infected adults show reduced proportions of non-classical monocytes only. We also observe increased proportions of CD63+ activated neutrophils during the acute phase to SARS-CoV-2 in infected children. Children and adults exposed to SARS-CoV-2 but negative on PCR testing display increased proportions of low-density neutrophils that we observe up to 7 weeks post exposure. This study characterises the innate immune response during SARS-CoV-2 infection and household exposure in children.Entities:
Year: 2021 PMID： 33597531 DOI： 10.1038/s41467-021-21414-x
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919