Literature DB >> 3359682

Verbal deficits in Klinefelter (XXY) adults living in the community.

M E Porter1, H A Gardner, P DeFeudis, N S Endler.   

Abstract

Forty-two adult males--10 with Klinefelter's syndrome (karyotype XXY), 17 with normal sex chromosome karyotype (XY) but with physical signs of hypogonadism, and 15 presumed to be normal both chromosomally and hormonally--completed tests of Verbal and Nonverbal ability. It was predicted: a) that the XXY group would perform more poorly than the other two groups on tests of Verbal ability, and b) that the XY, hypogonadal group would perform more poorly than the others on tests of Non-verbal ability. The first hypothesis was supported. However, in spite of measurable verbal deficits, the XXY men (whose parents were more highly educated than those of the other two groups) did not appear to be underachievers. Rather, they were, in general, as well educated, as likely to be employed, and of socioeconomic status equivalent to that of the other men in the study. These findings are discussed briefly in terms of implications for early childhood education and genetic counselling. The second hypothesis was not supported: this is attributed to presumed heterogeneity of etiology of hypogonadism in the XY, hypogonadal group.

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Year:  1988        PMID: 3359682     DOI: 10.1111/j.1399-0004.1988.tb03445.x

Source DB:  PubMed          Journal:  Clin Genet        ISSN: 0009-9163            Impact factor:   4.438


  3 in total

Review 1.  Recent developments in the application of the nonverbal learning disabilities model.

Authors:  Brenna C McDonald
Journal:  Curr Psychiatry Rep       Date:  2002-10       Impact factor: 5.285

2.  An extra X or Y chromosome: contrasting the cognitive and motor phenotypes in childhood in boys with 47,XYY syndrome or 47,XXY Klinefelter syndrome.

Authors:  Judith L Ross; Martha P D Zeger; Harvey Kushner; Andrew R Zinn; David P Roeltgen
Journal:  Dev Disabil Res Rev       Date:  2009

Review 3.  Neurocognitive outcomes of individuals with a sex chromosome trisomy: XXX, XYY, or XXY: a systematic review.

Authors:  Victoria Leggett; Patricia Jacobs; Kate Nation; Gaia Scerif; Dorothy V M Bishop
Journal:  Dev Med Child Neurol       Date:  2010-01-05       Impact factor: 5.449

  3 in total

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