Baixue Jia1, Zeguang Ren2, Maxim Mokin2, W Scott Burgin2, Clayton T Bauer2, Jens Fiehler3, Dapeng Mo1, Ning Ma1, Feng Gao1, Xiaochuan Huo1, Gang Luo1, Anxin Wang4, Yuesong Pan4, Ligang Song1, Xuan Sun1, Xuelei Zhang1, Liqiang Gui5, Cunfeng Song6, Ya Peng7, Jin Wu8, Shijun Zhao9, Junfeng Zhao10, Zhiming Zhou11, Yongli Li12, Ping Jing13, Lei Yang14, Yajie Liu15, Qingshi Zhao16, Yan Liu17, Xiaoxiang Peng18, Qingchun Gao19, Zaiyu Guo20, Wenhuo Chen21, Weirong Li22, Xiaojiang Cheng23, Yun Xu24, Yongqiang Zhang25, Guilian Zhang26, Yijiu Lu27, Xinyu Lu28, Dengxiang Wang29, Yan Wang30, Hao Li31, Li Ling32, Guangge Peng1, Jingyu Zhang1, Kai Zhang1, Shuo Li1, Zhongqi Qi1, Haifeng Xu1, Xu Tong1, Gaoting Ma1, Raynald Liu1, Xu Guo33, Yiming Deng1, Xinyi Leng34, Thomas W Leung34, David S Liebeskind35, Yilong Wang36,37, Yongjun Wang, Zhongrong Miao1. 1. Interventional Neuroradiology Center (B.J., D.M., N.M., F.G., X.H., G.L., L.S., X.S., X.Z., G.P., J. Zhang, K.Z., S.L., Z.Q., H.X., X.T., G.M., R.L., Y.D., Z.M.), Beijing Tiantan Hospital, Capital Medical University. 2. Department of Neurosurgery, University of South Florida (Z.R., M.M., W.S.B., C.T.B.). 3. Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Germany (J.F.). 4. China National Clinical Research Center for Neurological Diseases (A.W., Y. Pan), Beijing Tiantan Hospital, Capital Medical University. 5. Department of Interventional Neuroradiology, Langfang Changzheng Hospital, China (L.G.). 6. Department of Interventional Neuroradiology, Liaocheng Third People's Hospital, China (C.S.). 7. Department of Neurosurgery, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, China (Y. Peng). 8. Department of Neurology, Second Affiliated Hospital of Nanjing Medical University, China (J.W.). 9. Department of Interventional Radiology, Fengrun District People's Hospital of Tangshan City, China (S.Z.). 10. Department of Neurology, SiPing Central People's Hospital, China (J. Zhao). 11. Department of Neurology, Yijishan Hospital of Wannan Medical College, China (Z.Z.). 12. Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, China (Y. Li). 13. Department of Neurology, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, China (P.J.). 14. Department of Neurosurgery, The First Hospital of Shijiazhuang, China (L.Y.). 15. Department of Neurology, Shenzhen Hospital of Southern Medical University, China (Yajie Liu). 16. Department of Neurology, The People's Hospital of Longhua, China (Q.Z.). 17. Department of Neurology, Jingjiang People's Hospital, The Seventh Affiliated Hospital of Yangzhou University, China (Yan Liu). 18. Department of Neurology, Hubei Third People's Hospital, China (X.P.). 19. Department of Neurology, Institute of Neuroscience, The Second Affiliated Hospital of Guangzhou Medical University, China (Q.G.). 20. Department of Neurosurgery, Tianjin TEDA Hospital, China (Z.G.). 21. Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, China (W.C.). 22. Department of Neurology, Taiyuan Central Hospital, China (W.L.). 23. Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, China (X.C.). 24. Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, China (Y.X.). 25. Department of Neurosurgery, Wenling First People's Hospital, China (Y.Z.). 26. Department of Neurology, The Second Affiliated Hospital of Xi'an Jiaotong University, China (G.Z.). 27. Department of Internal Neurology, The First People's Hospital of Yulin, China (Y. Lu). 28. Department of Neurosurgery, Zhenjiang First People's Hospital, China (X. Lu). 29. Department of Neurology, Qitaihe Coal General Hospital, China (D.W.). 30. Stroke Center, People's Hospital of Tangshan City, China (Yan Wang). 31. Department of Neurology, Affiliated Hospital Guilin Medical University, China (H.L.). 32. Department of Neurology, The Affiliated Hospital of Hebei University, China (L.L.). 33. Department of Neurointervetion, Beijing Anzhen Hospital, Capital Medical University, China (X.G.). 34. Department of Medicine and Therapeutics, Chinese University of Hong Kong, China (X. Leng, T.W.L.). 35. Department of Neurology, University of California (D.S.L.). 36. Department of Neurology, China National Clinical Research Center for Neurological Diseases, Tiantan Clinical Trial and Research Center for Stroke (Yilong Wang), Beijing Tiantan Hospital, Capital Medical University. 37. Beijing Tiantan Hospital, Capital Medical University, China (Yongjun Wang).
Abstract
BACKGROUND AND PURPOSE: The benefit of endovascular treatment (EVT) for large vessel occlusion in clinical practice in developing countries like China needs to be confirmed. The aim of the study was to determine whether the benefit of EVT for acute ischemic stroke in randomized trials could be generalized to clinical practice in Chinese population. METHODS: We conducted a prospective registry of EVT at 111 centers in China. Patients with acute ischemic stroke caused by imaging-confirmed intracranial large vessel occlusion and receiving EVT were included. The primary outcome was functional independence at 90 days defined as a modified Rankin Scale score of 0 to 2. Outcomes of specific subgroups in the anterior circulation were reported and logistic regression was performed to predict the primary outcome. RESULTS: Among the 1793 enrolled patients, 1396 (77.9%) had anterior circulation large vessel occlusion (median age, 66 [56-73] years) and 397 (22.1%) had posterior circulation large vessel occlusion (median age, 64 [55-72] years). Functional independence at 90 days was reached in 45% and 44% in anterior and posterior circulation groups, respectively. For anterior circulation population, underlying intracranial atherosclerotic disease was identified in 29% of patients, with higher functional independence at 90 days (52% versus 44%; P=0.0122) than patients without intracranial atherosclerotic disease. In the anterior circulation population, after adjusting for baseline characteristics, procedure details, and early outcomes, the independent predictors for functional independence at 90 days were age <66 years (odds ratio [OR], 1.733 [95% CI, 1.213-2.476]), time from onset to puncture >6 hours (OR, 1.536 [95% CI, 1.065-2.216]), local anesthesia (OR, 2.194 [95% CI, 1.325-3.633]), final modified Thrombolysis in Cerebral Infarction 2b/3 (OR, 2.052 [95% CI, 1.085-3.878]), puncture-to-reperfusion time ≤1.5 hours (OR, 1.628 [95% CI, 1.098-2.413]), and National Institutes of Health Stroke Scale score 24 hours after the procedure <11 (OR, 9.126 [95% CI, 6.222-13.385]). CONCLUSIONS: Despite distinct characteristics in the Chinese population, favorable outcome of EVT can be achieved in clinical practice in China. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03370939.
BACKGROUND AND PURPOSE: The benefit of endovascular treatment (EVT) for large vessel occlusion in clinical practice in developing countries like China needs to be confirmed. The aim of the study was to determine whether the benefit of EVT for acute ischemic stroke in randomized trials could be generalized to clinical practice in Chinese population. METHODS: We conducted a prospective registry of EVT at 111 centers in China. Patients with acute ischemic stroke caused by imaging-confirmed intracranial large vessel occlusion and receiving EVT were included. The primary outcome was functional independence at 90 days defined as a modified Rankin Scale score of 0 to 2. Outcomes of specific subgroups in the anterior circulation were reported and logistic regression was performed to predict the primary outcome. RESULTS: Among the 1793 enrolled patients, 1396 (77.9%) had anterior circulation large vessel occlusion (median age, 66 [56-73] years) and 397 (22.1%) had posterior circulation large vessel occlusion (median age, 64 [55-72] years). Functional independence at 90 days was reached in 45% and 44% in anterior and posterior circulation groups, respectively. For anterior circulation population, underlying intracranial atherosclerotic disease was identified in 29% of patients, with higher functional independence at 90 days (52% versus 44%; P=0.0122) than patients without intracranial atherosclerotic disease. In the anterior circulation population, after adjusting for baseline characteristics, procedure details, and early outcomes, the independent predictors for functional independence at 90 days were age <66 years (odds ratio [OR], 1.733 [95% CI, 1.213-2.476]), time from onset to puncture >6 hours (OR, 1.536 [95% CI, 1.065-2.216]), local anesthesia (OR, 2.194 [95% CI, 1.325-3.633]), final modified Thrombolysis in Cerebral Infarction 2b/3 (OR, 2.052 [95% CI, 1.085-3.878]), puncture-to-reperfusion time ≤1.5 hours (OR, 1.628 [95% CI, 1.098-2.413]), and National Institutes of Health Stroke Scale score 24 hours after the procedure <11 (OR, 9.126 [95% CI, 6.222-13.385]). CONCLUSIONS: Despite distinct characteristics in the Chinese population, favorable outcome of EVT can be achieved in clinical practice in China. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03370939.