William Mellick1, James J Prisciandaro2, Helena Brenner1, Delisa Brown1, Bryan K Tolliver1. 1. Addiction Sciences Division, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA. 2. Addiction Sciences Division, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA, priscian@musc.edu.
Abstract
INTRODUCTION: Shared neurobehavioral characteristics of bipolar disorder (BD) and alcohol dependence (AD), including heightened sensitivity to reward (SR), may account for high rates of BD and AD co-occurrence (BD + AD). However, empirical research is lacking. The present multimethod investigation examined SR and sensitivity to punishment (SP) among these patient groups using a reliable and well-validated self-report questionnaire of SR and SP along with a laboratory task specifically designed to distinguish SR and SP activation. METHODS: One-hundred participants formed 4 groups: BD + AD (n = 40), BD (n = 18), AD (n = 25), and healthy controls (n = 17). Clinical interviews were administered, and participants completed the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSR-Q) and the Point Score Reaction Test behavioral task. Pearson correlations, hierarchical linear regression, and 2 × 2 factorial general linear modeling with Bonferroni-corrected pairwise comparisons were performed. RESULTS: BD and AD main effects were significant on self-reported SR and SP; however, BD × AD interactions were not. BD + AD individuals were significantly higher on self-reported SR than BD and AD individuals, yet all clinical groups were similar on SP. Behavioral response times did not distinguish groups nor did they associate with self-report data. DISCUSSION/ CONCLUSION: BD and AD had additive, rather than interactive, effects on self-reported SR and SP. The methods employed, paired with their application to the present sample, may account for a lack of positive findings with behavioral data.
INTRODUCTION: Shared neurobehavioral characteristics of bipolar disorder (BD) and alcohol dependence (AD), including heightened sensitivity to reward (SR), may account for high rates of BD and AD co-occurrence (BD + AD). However, empirical research is lacking. The present multimethod investigation examined SR and sensitivity to punishment (SP) among these patient groups using a reliable and well-validated self-report questionnaire of SR and SP along with a laboratory task specifically designed to distinguish SR and SP activation. METHODS: One-hundred participants formed 4 groups: BD + AD (n = 40), BD (n = 18), AD (n = 25), and healthy controls (n = 17). Clinical interviews were administered, and participants completed the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSR-Q) and the Point Score Reaction Test behavioral task. Pearson correlations, hierarchical linear regression, and 2 × 2 factorial general linear modeling with Bonferroni-corrected pairwise comparisons were performed. RESULTS: BD and AD main effects were significant on self-reported SR and SP; however, BD × AD interactions were not. BD + AD individuals were significantly higher on self-reported SR than BD and AD individuals, yet all clinical groups were similar on SP. Behavioral response times did not distinguish groups nor did they associate with self-report data. DISCUSSION/ CONCLUSION: BD and AD had additive, rather than interactive, effects on self-reported SR and SP. The methods employed, paired with their application to the present sample, may account for a lack of positive findings with behavioral data.
Authors: James J Prisciandaro; Stacia M DeSantis; Cody Chiuzan; Delisa G Brown; Kathleen T Brady; Bryan K Tolliver Journal: Alcohol Clin Exp Res Date: 2011-09-20 Impact factor: 3.455
Authors: Bryan K Tolliver; Stacia M Desantis; Delisa G Brown; James J Prisciandaro; Kathleen T Brady Journal: Bipolar Disord Date: 2012-02 Impact factor: 6.744
Authors: Lauren B Alloy; Lyn Y Abramson; Patricia D Walshaw; Alex Cogswell; Louisa D Grandin; Megan E Hughes; Brian M Iacoviello; Wayne G Whitehouse; Snezana Urosevic; Robin Nusslock; Michael E Hogan Journal: Bipolar Disord Date: 2008-03 Impact factor: 6.744
Authors: J J Prisciandaro; B K Tolliver; A P Prescot; H M Brenner; P F Renshaw; T R Brown; R F Anton Journal: Transl Psychiatry Date: 2017-07-04 Impact factor: 6.222