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Literature DB >> 335960

Clinical and bacteriological evaluation of netilmicin in gram-negative infections.

J Klastersky, F Meunier-Carpentier, L Coppens-Kahan, D Daneau, J M Prevost.

Abstract

A preliminary study was conducted with netilmicin, a new aminoglycoside antibiotic. Its effectiveness was evaluated in vitro against 546 strains of Enterobacteriaceae and Pseudomonas aeruginosa isolated from clinical material. Its effectiveness against gentamicin-susceptible strains was roughly similar to that of gentamicin and other newer aminoglycoside antibiotics. Cross-resistance to netilmicin was found in 9 of 44 gentamicin-resistant strains. A favorable clinical response was observed in 70% of the patients treated with a dose of netilmicin ranging from 4.5 to 7.5 mg/kg. However, the appearance of granular casts was seen in 7 of 10 patients receiving the higher dosage of netilmicin (7.5 mg/kg) and a rise in blood urea nitrogen or serum creatinine levels was observed in 5 of these patients.

Entities: Chemical Species

Mesh：

Substances：
Gentamicins
Sisomicin

Year: 1977 PMID： 335960 PMCID： PMC429954 DOI： 10.1128/AAC.12.4.503

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

1. Clinical significance of in vitro synergism between antibiotics in gram-negative infections.

Authors: J Klastersky; R Cappel; D Daneau
Journal: Antimicrob Agents Chemother Date: 1972-12 Impact factor: 5.191

2. Antimicrobial effectiveness ofkanamycin, aminosidin, BB-K8, sisomicin, gentamicin and tobramycin combined with carbenicillin or cephalothin against gram-negative rods.

Authors: J Klastersky; B Nyamubeya; L Vandenborre
Journal: J Med Microbiol Date: 1974-11 Impact factor: 2.472

3. Controlled comparison of amikacin and gentamicin.

Authors: C R Smith; K L Baughman; C Q Edwards; J F Rogers; P S Lietman
Journal: N Engl J Med Date: 1977-02-17 Impact factor: 91.245

4. In vitro susceptibility of gentamicin-resistant Enterobacteriaceae and Pseudomonas aeruginosa to netilmicin and selected aminoglycoside antibiotics.

Authors: R D Meyer; L L Draus; K A Pasieczinik
Journal: Antimicrob Agents Chemother Date: 1976-10 Impact factor: 5.191

5. In vitro activity of gentamicin, amikacin and netilmicin alone and in combination with carbenicillin against Serratia marcescens.

Authors: S M Pogwizd; S A Lerner
Journal: Antimicrob Agents Chemother Date: 1976-12 Impact factor: 5.191

Clinical and bacteriological evaluation of netilmicin in gram-negative infections.

1. Clinical significance of in vitro synergism between antibiotics in gram-negative infections.

2. Antimicrobial effectiveness ofkanamycin, aminosidin, BB-K8, sisomicin, gentamicin and tobramycin combined with carbenicillin or cephalothin against gram-negative rods.

3. Controlled comparison of amikacin and gentamicin.

4. In vitro susceptibility of gentamicin-resistant Enterobacteriaceae and Pseudomonas aeruginosa to netilmicin and selected aminoglycoside antibiotics.

5. In vitro activity of gentamicin, amikacin and netilmicin alone and in combination with carbenicillin against Serratia marcescens.

6. In vitro studies with netilmicin compared with amikacin, gentamicin, and tobramycin.

7. Antimicrobial activity in vitro of netilmicin and comparison with sisomicin, gentamicin, and tobramycin.

8. Interaction of purulent material with antibiotics used to treat Pseudomonas infections.

9. In vitro activity of netilmicin, gentamicin, and amikacin.

10. Comparison of amikacin and tobramycin in the treatment of infection in patients with cancer.

1. Prospective comparative study of efficacy and toxicity of netilmicin and amikacin.

2. Tentative interpretive criteria for the diffusion susceptibility test using 30-microgram netilmicin disks.

3. Therapeutic experience with netilmicin.

4. Clinical efficacy and toxicity of netilmicin in the treatment of gram-negative infections.

5. Pharmacology and efficacy of netilmicin.

6. Netilmicin in gram-negative bacterial infections.

Review 7. Netilmicin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.