Literature DB >> 3359557

In vitro antiproliferative activity of 2'-(2-hydroxyphenyl)-2'-thiazoline-4'-carboxylic acid and its methyl ester on L1210 and P388 murine neoplasms.

G T Elliot1, K F Kelly, R L Bonna, T R Wardlaw, E R Burns.   

Abstract

The activity of three iron chelators, methyl [2'-(2-hydroxyphenyl)-2'-thiazoline-4'-carboxylate] (MTL); 2'-(2-hydroxyphenyl)-2'-thiazoline-4'-carboxylic acid (TFAL); and 2-hydroxyphenyl-imido-ethyl-ether (Imidate), regarding antiproliferative, cytocidal, and cell-cycle effects are reported and compared with hydroxyurea (HU). In vitro, against L1210 and P388 murine neoplasms, MTL and TFAL displayed substantially greater antiproliferative activity than HU, although Imidate displayed no appreciable activity. MTL also induced a statistically more complete G1/S cell-boundary block than did HU at equimolar concentrations (100 microM). The IC50 values produced by MTL and TFAL were low enough (less than or equal to 20 microM) to warrant further testing of these chelators as potential antineoplastic agents.

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Year:  1988        PMID： 3359557     DOI： 10.1007/bf00262776

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  21 in total

1.  Mechanism of inhibition of ribonucleoside diphosphate reductase by a-(N)-heterocyclic aldehyde thiosemicarbazones.

Authors:  A C Sartorelli; K C Agrawal; E C Moore
Journal:  Biochem Pharmacol       Date:  1971-11       Impact factor: 5.858

2.  Hydroxyurea retards the progression of G2 cells.

Authors:  M H Schneiderman; B F Kimler; D B Leeper; W C Dewey
Journal:  Exp Cell Res       Date:  1978-09       Impact factor: 3.905

3.  Effect of iron deficiency and desferrioxamine on DNA synthesis in human cells.

Authors:  A V Hoffbrand; K Ganeshaguru; J W Hooton; M H Tattersall
Journal:  Br J Haematol       Date:  1976-08       Impact factor: 6.998

4.  Iron homeostasis in plasmacytoma-bearing mice.

Authors:  S G Schade
Journal:  Cancer Res       Date:  1976-02       Impact factor: 12.701

Review 5.  Idiopathic hemochromatosis, an interim report.

Authors:  M S Milder; J D Cook; S Stray; C A Finch
Journal:  Medicine (Baltimore)       Date:  1980-01       Impact factor: 1.889

6.  A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis.

Authors:  L L Vindeløv; I J Christensen; N I Nissen
Journal:  Cytometry       Date:  1983-03

7.  Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.

Authors:  R Sutherland; D Delia; C Schneider; R Newman; J Kemshead; M Greaves
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

8.  Iron: its intracellular localization and possible role in cell division.

Authors:  E Robbins; T Pederson
Journal:  Proc Natl Acad Sci U S A       Date:  1970-08       Impact factor: 11.205

9.  Iron and neoplasia.

Authors:  E D Weinberg
Journal:  Biol Trace Elem Res       Date:  1981-03       Impact factor: 3.738

10.  The cancer pattern in African gold miners.

Authors:  M A Robertson; J S Harington; E Bradshaw
Journal:  Br J Cancer       Date:  1971-09       Impact factor: 7.640
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  4 in total

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Journal:  ACS Infect Dis       Date:  2021-02-12       Impact factor: 5.084

2.  Biosynthesis of pyochelin and dihydroaeruginoic acid requires the iron-regulated pchDCBA operon in Pseudomonas aeruginosa.

Authors:  L Serino; C Reimmann; P Visca; M Beyeler; V D Chiesa; D Haas
Journal:  J Bacteriol       Date:  1997-01       Impact factor: 3.490

3.  Synthesis, anticancer, and anti-inflammatory activity evaluation of methanesulfonamide and amidine derivatives of 3,4-diaryl-2-imino-4-thiazolines.

Authors:  Sham M Sondhi; Reshma Rani; P P Gupta; S K Agrawal; A K Saxena
Journal:  Mol Divers       Date:  2009-03-07       Impact factor: 2.943

4.  (R)-2-Phenyl-4,5-Dihydrothiazole-4-Carboxamide Derivatives Containing a Diacylhydrazine Group: Synthesis, Biological Evaluation, and SARs.

Authors:  Feng-Yun Li; Jing-Bo Liu; Jia-Ning Gong; Gen Li
Journal:  Molecules       Date:  2019-12-04       Impact factor: 4.411
  4 in total

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