Literature DB >> 33594378

CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants.

Andrew D Redd1,2, Alessandra Nardin3, Hassen Kared3, Evan M Bloch4, Andrew Pekosz5, Oliver Laeyendecker1,2, Brian Abel3, Michael Fehlings3, Thomas C Quinn1,2, Aaron Ar Tobian4.   

Abstract

This study examined whether CD8+ T-cell responses from COVID-19 convalescent individuals(n=30) potentially maintain recognition of the major SARS-CoV-2 variants. Out of 45 mutations assessed, only one from the B.1.351 Spike overlapped with a low-prevalence CD8+ epitope, suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.

Entities:  

Year:  2021        PMID： 33594378      PMCID： PMC7885937          DOI： 10.1101/2021.02.11.21251585

Source DB:  PubMed          Journal:  medRxiv


  5 in total

1.  Role of strong anchor residues in the effective binding of 10-mer and 11-mer peptides to HLA-A*2402 molecules.

Authors:  M Ibe; Y I Moore; K Miwa; Y Kaneko; S Yokota; M Takiguchi
Journal:  Immunogenetics       Date:  1996       Impact factor: 2.846

2.  Structure of replicating SARS-CoV-2 polymerase.

Authors:  Hauke S Hillen; Goran Kokic; Lucas Farnung; Christian Dienemann; Dimitry Tegunov; Patrick Cramer
Journal:  Nature       Date:  2020-05-21       Impact factor: 49.962

3.  SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals.

Authors:  Hassen Kared; Andrew D Redd; Evan M Bloch; Tania S Bonny; Hermi Sumatoh; Faris Kairi; Daniel Carbajo; Brian Abel; Evan W Newell; Maria P Bettinotti; Sarah E Benner; Eshan U Patel; Kirsten Littlefield; Oliver Laeyendecker; Shmuel Shoham; David Sullivan; Arturo Casadevall; Andrew Pekosz; Alessandra Nardin; Michael Fehlings; Aaron Ar Tobian; Thomas C Quinn
Journal:  J Clin Invest       Date:  2021-03-01       Impact factor: 14.808

4.  Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases.

Authors:  Alison Tarke; John Sidney; Conner K Kidd; Jennifer M Dan; Sydney I Ramirez; Esther Dawen Yu; Jose Mateus; Ricardo da Silva Antunes; Erin Moore; Paul Rubiro; Nils Methot; Elizabeth Phillips; Simon Mallal; April Frazier; Stephen A Rawlings; Jason A Greenbaum; Bjoern Peters; Davey M Smith; Shane Crotty; Daniela Weiskopf; Alba Grifoni; Alessandro Sette
Journal:  Cell Rep Med       Date:  2021-01-26

5.  Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population.

Authors:  Sabra L Klein; Andrew Pekosz; Han-Sol Park; Rebecca L Ursin; Janna R Shapiro; Sarah E Benner; Kirsten Littlefield; Swetha Kumar; Harnish Mukesh Naik; Michael J Betenbaugh; Ruchee Shrestha; Annie A Wu; Robert M Hughes; Imani Burgess; Patricio Caturegli; Oliver Laeyendecker; Thomas C Quinn; David Sullivan; Shmuel Shoham; Andrew D Redd; Evan M Bloch; Arturo Casadevall; Aaron Ar Tobian
Journal:  J Clin Invest       Date:  2020-11-02       Impact factor: 14.808
  5 in total

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