| Literature DB >> 33594056 |
Camille Bourgneuf1,2, Danielle Bailbé3, Antonin Lamazière1,4, Charlotte Dupont1,2,5, Marthe Moldes1,2, Dominique Farabos1,4, Natacha Roblot1,2, Camille Gauthier1,2, Emmanuelle Mathieu d'Argent1,2,5, Joelle Cohen-Tannoudji3, Danielle Monniaux6, Bruno Fève1,2,7, Jamileh Movassat3, Nathalie di Clemente1,2, Chrystèle Racine8,9,10.
Abstract
Polycystic ovary syndrome (PCOS) is characterized by an oligo-anovulation, hyperandrogenism and polycystic ovarian morphology combined with major metabolic disturbances. However, despite the high prevalence and the human and economic consequences of this syndrome, its etiology remains unknown. In this study, we show that female Goto-Kakizaki (GK) rats, a type 2 diabetes mellitus model, encapsulate naturally all the reproductive and metabolic hallmarks of lean women with PCOS at puberty and in adulthood. The analysis of their gestation and of their fetuses demonstrates that this PCOS-like phenotype is developmentally programmed. GK rats also develop features of ovarian hyperstimulation syndrome. Lastly, a comparison between GK rats and a cohort of women with PCOS reveals a similar reproductive signature. Thus, this spontaneous rodent model of PCOS represents an original tool for the identification of the mechanisms involved in its pathogenesis and for the development of novel strategies for its treatment.Entities:
Year: 2021 PMID： 33594056 DOI： 10.1038/s41467-021-21308-y
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919