Literature DB >> 33593378

Translational research in Uganda: linking basic science to bedside medicine in a resource limited setting.

Richard Kwizera1, Emmanuel Mande2, Denis Omali2, Samuel Okurut2, Sheila Nabweyambo2, Rose Nabatanzi2, Damalie Nakanjako2,3, David B Meya2,3.   

Abstract

BACKGROUND: Translational research is a process of applying knowledge from basic biology and clinical trials to techniques and tools that address critical medical needs. Translational research is less explored in the Ugandan health system, yet, it is fundamental in enhancing human health and well-being. With the current high disease burden in Uganda, there are many opportunities for exploring, developing and utilising translational research. MAIN BODY: In this article, we described the current state, barriers and opportunities for translational research in Uganda. We noted that translational research is underutilised and hindered by limited funding, collaborations, laboratory infrastructure, trained personnel, equipment and research diversity. However, with active collaborations and funding, it is possible to set up and develop thriving translational research in Uganda. Researchers need to leverage existing international collaborations to enhance translational research capacity development.
CONCLUSION: Expanding the integration of clinical and translational research in Uganda health care system will improve clinical care.

Entities:  

Keywords:  Bench-to-bedside research; Laboratory research; Translational medicine; Translational research; Translational science; Uganda

Mesh:

Year:  2021        PMID: 33593378      PMCID: PMC7887792          DOI: 10.1186/s12967-021-02747-z

Source DB:  PubMed          Journal:  J Transl Med        ISSN: 1479-5876            Impact factor:   5.531


  18 in total

1.  The meaning of translational research and why it matters.

Authors:  Steven H Woolf
Journal:  JAMA       Date:  2008-01-09       Impact factor: 56.272

2.  Defining translational research: implications for training.

Authors:  Doris McGartland Rubio; Ellie E Schoenbaum; Linda S Lee; David E Schteingart; Paul R Marantz; Karl E Anderson; Lauren Dewey Platt; Adriana Baez; Karin Esposito
Journal:  Acad Med       Date:  2010-03       Impact factor: 6.893

3.  Cerebrospinal fluid biomarkers and HIV-associated neurocognitive disorders in HIV-infected individuals in Rakai, Uganda.

Authors:  Ned Sacktor; David R Boulware; Mahsa Abassi; Bozena M Morawski; Gertrude Nakigozi; Noeline Nakasujja; Xiangrong Kong; David B Meya; Kevin Robertson; Ronald Gray; Maria J Wawer
Journal:  J Neurovirol       Date:  2016-12-19       Impact factor: 2.643

4.  Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis.

Authors:  David R Boulware; David B Meya; Conrad Muzoora; Melissa A Rolfes; Katherine Huppler Hullsiek; Abdu Musubire; Kabanda Taseera; Henry W Nabeta; Charlotte Schutz; Darlisha A Williams; Radha Rajasingham; Joshua Rhein; Friedrich Thienemann; Melanie W Lo; Kirsten Nielsen; Tracy L Bergemann; Andrew Kambugu; Yukari C Manabe; Edward N Janoff; Paul R Bohjanen; Graeme Meintjes
Journal:  N Engl J Med       Date:  2014-06-26       Impact factor: 91.245

5.  Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults.

Authors:  Pauline Byakika-Kibwika; Mohammed Lamorde; Jonathan Mayito; Lillian Nabukeera; Rhoda Namakula; Harriet Mayanja-Kizza; Elly Katabira; Muhammad Ntale; Nadine Pakker; Mairin Ryan; Warunee Hanpithakpong; Joel Tarning; Niklas Lindegardh; Peter J de Vries; Saye Khoo; David Back; Concepta Merry
Journal:  J Antimicrob Chemother       Date:  2012-06-11       Impact factor: 5.790

6.  Cryptococcal genotype influences immunologic response and human clinical outcome after meningitis.

Authors:  Darin L Wiesner; Oleksandr Moskalenko; Jennifer M Corcoran; Tami McDonald; Melissa A Rolfes; David B Meya; Henry Kajumbula; Andrew Kambugu; Paul R Bohjanen; Joseph F Knight; David R Boulware; Kirsten Nielsen
Journal:  MBio       Date:  2012-09-25       Impact factor: 7.867

7.  Evaluation of portable point-of-care CD4 counter with high sensitivity for detecting patients eligible for antiretroviral therapy.

Authors:  Yukari C Manabe; Yaping Wang; Ali Elbireer; Brandon Auerbach; Barbara Castelnuovo
Journal:  PLoS One       Date:  2012-04-19       Impact factor: 3.240

8.  Mycetoma in Uganda: A neglected tropical disease.

Authors:  Richard Kwizera; Felix Bongomin; David B Meya; David W Denning; Ahmed H Fahal; Robert Lukande
Journal:  PLoS Negl Trop Dis       Date:  2020-04-29

9.  Beyond bench and bedside: disentangling the concept of translational research.

Authors:  Anna Laura van der Laan; Marianne Boenink
Journal:  Health Care Anal       Date:  2015-03

10.  Antimicrobial Resistance of Neisseria Gonorrhoeae in a Newly Implemented Surveillance Program in Uganda: Surveillance Report.

Authors:  Meklit Workneh; Matthew M Hamill; Francis Kakooza; Emmanuel Mande; Jessica Wagner; Olive Mbabazi; Rodney Mugasha; Henry Kajumbula; Richard Walwema; Jonathan Zenilman; Patrick Musinguzi; Peter Kyambadde; Mohammed Lamorde; Yukari C Manabe
Journal:  JMIR Public Health Surveill       Date:  2020-06-10
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  1 in total

1.  Misdiagnosis of chronic pulmonary aspergillosis as pulmonary tuberculosis at a tertiary care center in Uganda: a case series.

Authors:  Richard Kwizera; Andrew Katende; Felix Bongomin; Lydia Nakiyingi; Bruce J Kirenga
Journal:  J Med Case Rep       Date:  2021-03-30
  1 in total

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