Edite Sadiku1, Eqerem Hasani2,3, Indrit Këlliçi3,4, Iris Mone3,5, Fatjona Kraja3,6, Bledar Kraja7,8, Genc Burazeri9. 1. University Clinic of Gastrohepatology and Hepatology Service, University Hospital Center "Mother Teresa", Dibra Street 371, 1001, Tirana, Albania. 2. Emergency Departments, University Hospital Center Mother Teresa, Dibra Street 371, Tirana, Albania. 3. Division of Physiology, Department of Biomedical and Experimental Sciences, Faculty of Medicine, University of Medicine, Dibra Street 371, Tirana, Albania. 4. Endoscopy Unit, Service of Surgery, Regional Hospital Durrës, Telat Noga Street, Durrës, Albania. 5. Department of Laboratory, University Hospital Center Mother Teresa, Dibra Street 371, Tirana, Albania. 6. University Clinic of Oncology, University Hospital Center Mother Teresa, Dibra Street 371, Tirana, Albania. 7. University Clinic of Gastrohepatology and Hepatology Service, University Hospital Center "Mother Teresa", Dibra Street 371, 1001, Tirana, Albania. bledarkraja@yahoo.com. 8. Division of Physiology, Department of Biomedical and Experimental Sciences, Faculty of Medicine, University of Medicine, Dibra Street 371, Tirana, Albania. bledarkraja@yahoo.com. 9. Department of International Health, School for Public Health and Primary Care (CAPHRI), Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Abstract
INTRODUCTION: Erosive reflux esophagitis caused a large clinical spectrum of symptoms. Our aim was to assess the prevalence of extra-esophageal symptoms in individuals with and those without erosive esophagitis in Albania. METHODS: A case-control study was conducted at the Regional Hospital of Durres, the second main district in Albania, a transitional country in South Eastern Europe, including 248 patients with erosive esophagitis (aged 46.5 ± 16.3 years) and 273 controls (aged 46.4 ± 16.0 years; response rate: 70%) enrolled during the period January 2013-June 2014. Both cases and controls underwent upper endoscopy. Information on socio-demographic characteristics and lifestyle factors was also collected. Binary logistic regression was used to assess the association of erosive esophagitis and extra-esophageal symptoms. RESULTS: Patients with erosive esophagitis had a higher prevalence of excessive alcohol consumption, smoking, sedentarity, non-Mediterranean diet and obesity compared to their control counterparts (9% vs. 5%, 70% vs. 49%, 31% vs. 17%, 61% vs. 49% and 22% vs. 9%, respectively). Upon adjustment for all socio-demographic characteristics and lifestyle/behavioral factors, there was evidence of a strong association of erosive esophagitis with chronic cough (OR = 3.2, 95% CI = 1.7-5.8), and even more so with laryngeal disorders (OR = 4.4, 95% CI = 2.6-7.5). In all models, the association of erosive esophagitis with any extra-esophageal symptoms was strong and mainly consistent with each of the symptoms separately (fully-adjusted model: OR = 4.6, 95% CI = 2.9-7.3). CONCLUSION: Our findings indicate that the prevalence of extra-esophageal symptoms is higher among patients with erosive esophagitis in a transitional country characterized conventionally by employment of a Mediterranean diet.
INTRODUCTION:Erosive reflux esophagitis caused a large clinical spectrum of symptoms. Our aim was to assess the prevalence of extra-esophageal symptoms in individuals with and those without erosive esophagitis in Albania. METHODS: A case-control study was conducted at the Regional Hospital of Durres, the second main district in Albania, a transitional country in South Eastern Europe, including 248 patients with erosive esophagitis (aged 46.5 ± 16.3 years) and 273 controls (aged 46.4 ± 16.0 years; response rate: 70%) enrolled during the period January 2013-June 2014. Both cases and controls underwent upper endoscopy. Information on socio-demographic characteristics and lifestyle factors was also collected. Binary logistic regression was used to assess the association of erosive esophagitis and extra-esophageal symptoms. RESULTS:Patients with erosive esophagitis had a higher prevalence of excessive alcohol consumption, smoking, sedentarity, non-Mediterranean diet and obesity compared to their control counterparts (9% vs. 5%, 70% vs. 49%, 31% vs. 17%, 61% vs. 49% and 22% vs. 9%, respectively). Upon adjustment for all socio-demographic characteristics and lifestyle/behavioral factors, there was evidence of a strong association of erosive esophagitis with chronic cough (OR = 3.2, 95% CI = 1.7-5.8), and even more so with laryngeal disorders (OR = 4.4, 95% CI = 2.6-7.5). In all models, the association of erosive esophagitis with any extra-esophageal symptoms was strong and mainly consistent with each of the symptoms separately (fully-adjusted model: OR = 4.6, 95% CI = 2.9-7.3). CONCLUSION: Our findings indicate that the prevalence of extra-esophageal symptoms is higher among patients with erosive esophagitis in a transitional country characterized conventionally by employment of a Mediterranean diet.
Authors: D García-Compeán; M V González; G Galindo; D A Mar; J L Treviño; R Martínez; F Bosques; H Maldonado Journal: Dig Dis Date: 2000 Impact factor: 2.404
Authors: C F Smit; J A van Leeuwen; L M Mathus-Vliegen; P P Devriese; A Semin; J Tan; P F Schouwenburg Journal: Arch Otolaryngol Head Neck Surg Date: 2000-07