Biotin enrichment in oligodendrocytes in the rat brain.

Cytochemical localization of endogenous biotin in the rat brain was detected by two different staining methods, avidin-biotin-HRP and goat-anti-biotin with HRP-rabbit-anti-goat. In both staining methods, oligodendrocytes were labeled to a far greater degree than other brain cells. This finding may be important for identification of the role of carbonic anhydrase, which is elevated in the oligodendrocyte, and it may help to explain how the oligodendrocyte generates large quantities of lipids for myelin production.