Literature DB >> 33592623

Endotoxin for Alcohol Research: A Call for Experimental Medicine Using Lipopolysaccharide Challenge.

Elizabeth M Burnette1,2, Erica N Grodin1, Naomi I Eisenberger1, Lara A Ray1,3,4.   

Abstract

Studies of inflammation in alcohol use disorder (AUD) are overwhelmingly preclinical, and translation to clinical samples is necessary. Endotoxin administration has been used successfully in humans to study mood disorders, offering a translational, reliable and safe model that may be validated in AUD research. We argue for the use of endotoxin challenge to elucidate the interplay between AUD and inflammation.
© The Author(s) 2021. Medical Council on Alcohol and Oxford University Press. All rights reserved.

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Year:  2021        PMID： 33592623      PMCID： PMC8557676          DOI： 10.1093/alcalc/agaa148

Source DB:  PubMed          Journal:  Alcohol Alcohol        ISSN： 0735-0414            Impact factor:   2.826


  10 in total

1.  PPARγ activation by pioglitazone does not suppress cravings for alcohol, and is associated with a risk of myopathy in treatment seeking alcohol dependent patients: a randomized controlled proof of principle study.

Authors:  Melanie L Schwandt; Nancy Diazgranados; John C Umhau; Laura E Kwako; David T George; Markus Heilig
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Review 2.  Human endotoxin administration as an experimental model in drug development.

Authors:  A F Suffredini; R J Noveck
Journal:  Clin Pharmacol Ther       Date:  2014-10       Impact factor: 6.875

3.  Chronic systemic endotoxin exposure: an animal model in experimental hepatic encephalopathy.

Authors:  Kai O Lindros; Harri A Järveläinen
Journal:  Metab Brain Dis       Date:  2005-12       Impact factor: 3.584

Review 4.  Alcoholic Hepatitis: A Review.

Authors:  Nooshin Hosseini; Julia Shor; Gyongyi Szabo
Journal:  Alcohol Alcohol       Date:  2019-07-01       Impact factor: 2.826

5.  Acute immunomodulatory effects of binge alcohol ingestion.

Authors:  Majid Afshar; Stephanie Richards; Dean Mann; Alan Cross; Gordon B Smith; Giora Netzer; Elizabeth Kovacs; Jeffrey Hasday
Journal:  Alcohol       Date:  2014-12-05       Impact factor: 2.405

6.  Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity.

Authors:  Sophie Leclercq; Sébastien Matamoros; Patrice D Cani; Audrey M Neyrinck; François Jamar; Peter Stärkel; Karen Windey; Valentina Tremaroli; Fredrik Bäckhed; Kristin Verbeke; Philippe de Timary; Nathalie M Delzenne
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-06       Impact factor: 11.205

Review 7.  The Microbiota, the Gut and the Brain in Eating and Alcohol Use Disorders: A 'Ménage à Trois'?

Authors:  Jamie E Temko; Sofia Bouhlal; Mehdi Farokhnia; Mary R Lee; John F Cryan; Lorenzo Leggio
Journal:  Alcohol Alcohol       Date:  2017-07-01       Impact factor: 2.826

8.  Characterization of a model of systemic inflammation in humans in vivo elicited by continuous infusion of endotoxin.

Authors:  D Kiers; R M Koch; L Hamers; J Gerretsen; E J M Thijs; L van Ede; N P Riksen; M Kox; P Pickkers
Journal:  Sci Rep       Date:  2017-01-05       Impact factor: 4.379

9.  Immune Response to an Acute Moderate Dose of Alcohol in Healthy Young Adults.

Authors:  Mollie A Monnig; Philip S Lamb; Jose M Parra; Patricia A Cioe; Christina M Martone; Peter M Monti; Gyongyi Szabo
Journal:  Alcohol Alcohol       Date:  2020-10-20       Impact factor: 3.913

Review 10.  Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression.

Authors:  Julie Lasselin; Mats Lekander; Sven Benson; Manfred Schedlowski; Harald Engler
Journal:  Mol Psychiatry       Date:  2020-09-01       Impact factor: 15.992
  10 in total

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