Literature DB >> 33592101

The Mosaic mtr Locus as Major Genetic Determinant of Azithromycin Resistance of Neisseria gonorrhoeae-Germany, 2018.

Sebastian Banhart1, Regina Selb2, Sandra Oehlmann1, Jennifer Bender3,4, Susanne Buder5, Klaus Jansen2, Dagmar Heuer1.   

Abstract

Within the German Gonococcal Resistance Network's (GORENET) Neisseria gonorrhoeae (NG) sample collection, azithromycin-resistant NG isolates increased from 4.3% in 2016 to 9.2% in 2018. We aim to understand this observed increase using whole genome sequencing of NG isolates combined with epidemiological and clinical data. Reduced susceptibility to azithromycin in 2018 was predominately clonal (NG multiantigen sequence typing G12302) and could mainly be attributed to the recently described mosaic-like mtr locus. Our data suggest that, together with horizontal gene transfer of resistance determinants and well-established point mutations, international spread of resistant lineages plays a major role regarding azithromycin resistance in Germany.
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  zzm321990 Neisseria gonorrhoeaezzm321990 ; Germany; MLST ST9363; NG-MAST ST12302; antibiotic resistance; azithromycin; genomic epidemiology; gonorrhea; macrolide; mosaic mtr locus

Mesh：

Substances：

Year:  2021        PMID： 33592101     DOI： 10.1093/infdis/jiab091

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  8 in total

1.  Global Emergence and Dissemination of Neisseria gonorrhoeae ST-9363 Isolates with Reduced Susceptibility to Azithromycin.

Authors:  Sandeep J Joseph; Jesse C Thomas; Matthew W Schmerer; John C Cartee; Sancta St Cyr; Karen Schlanger; Ellen N Kersh; Brian H Raphael; Kim M Gernert
Journal:  Genome Biol Evol       Date:  2022-01-04       Impact factor: 3.416

2.  Antimicrobial susceptibility of commensal Neisseria in a general population and men who have sex with men in Belgium.

Authors:  Jolein Gyonne Elise Laumen; Christophe Van Dijck; Saïd Abdellati; Irith De Baetselier; Gabriela Serrano; Sheeba Santhini Manoharan-Basil; Emmanuel Bottieau; Delphine Martiny; Chris Kenyon
Journal:  Sci Rep       Date:  2022-01-07       Impact factor: 4.379

3.  Increasing Azithromycin Resistance in Neisseria gonorrhoeae Due to NG-MAST 12302 Clonal Spread in Canada, 2015 to 2018.

Authors:  Pam Sawatzky; Walter Demczuk; Brigitte Lefebvre; Vanessa Allen; Mathew Diggle; Linda Hoang; Paul Van Caeseele; David Haldane; Jessica Minion; Michael R Mulvey; Irene Martin
Journal:  Antimicrob Agents Chemother       Date:  2022-01-03       Impact factor: 5.191

4.  In Vitro Activity of Ertapenem against Neisseria gonorrhoeae Clinical Isolates with Decreased Susceptibility or Resistance to Extended-Spectrum Cephalosporins in Nanjing, China (2013 to 2019).

Authors:  Xuechun Li; Wenjing Le; Xiangdi Lou; Caroline A Genco; Peter A Rice; Xiaohong Su
Journal:  Antimicrob Agents Chemother       Date:  2022-05-02       Impact factor: 5.938

5.  Choosing New Therapies for Gonorrhoea: We Need to Consider the Impact on the Pan-Neisseria Genome. A Viewpoint.

Authors:  Chris Kenyon; Jolein Laumen; Sheeba Manoharan-Basil
Journal:  Antibiotics (Basel)       Date:  2021-05-01

Review 6.  Bioinformatics tools used for whole-genome sequencing analysis of Neisseria gonorrhoeae: a literature review.

Authors:  Reema Singh; Anthony Kusalik; Jo-Anne R Dillon
Journal:  Brief Funct Genomics       Date:  2022-04-11       Impact factor: 4.840

7.  A Novel Method to Assess Antimicrobial Susceptibility in Commensal Oropharyngeal Neisseria-A Pilot Study.

Authors:  Jolein Gyonne Elise Laumen; Saïd Abdellati; Christophe Van Dijck; Delphine Martiny; Irith De Baetselier; Sheeba Santhini Manoharan-Basil; Dorien Van den Bossche; Chris Kenyon
Journal:  Antibiotics (Basel)       Date:  2022-01-13

8.  Markedly decreasing azithromycin susceptibility of Neisseria gonorrhoeae, Germany, 2014 to 2021.

Authors:  Regina Selb; Susanne Buder; Sandra Dudareva; Thalea Tamminga; Viviane Bremer; Sebastian Banhart; Dagmar Heuer; Klaus Jansen
Journal:  Euro Surveill       Date:  2021-08
  8 in total

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