Davide De Francesco 1 , Caroline A Sabin 1 , Alan Winston 2 , Michael N Rueschman 3,4 , Nicki D Doyle 2 , Jane Anderson 5 , Jaime H Vera 6 , Marta Boffito 7 , Memory Sachikonye 8 , Patrick W G Mallon 9 , Lewis Haddow 1,10 , Frank A Post 11 , Susan Redline 3,4,12 , Ken M Kunisaki 13,14 Show Affiliations »
Abstract
STUDY OBJECTIVES: We investigated associations between actigraphy-assessed sleep measures and cognitive function in people with and without HIV using different analytical approaches to better understand these associations and highlight differences in results obtained by these approaches. METHODS: Cognitive and 7-day/night actigraphy data were collected from people with HIV (PWH) and lifestyle-similar HIV-negative individuals from HIV and sexual health clinics in UK/Ireland. A global cognitive T-score was obtained averaging the standardized individual cognitive test scores accounting for socio-demographics. Average and standard deviation (SD) of eleven sleep measures over 7-days/nights were obtained. Rank regression, partial least-squares (PLS) regression, random forest, sleep dimension construct, and latent class analysis (LCA) were applied to evaluate associations between global T-scores and sleep measures. RESULTS: In 344 PWH (median age 57 years, 86% males), average sleep duration, efficiency and wake after sleep onset were not associated with global T-scores according to rank regression (p=0.51, p=0.09, p=0.16, respectively). In contrast, global T-scores associated with average and SD of length of nocturnal awakenings, SD of maintenance efficiency and average out-of-bed time when analyzed by PLS regression and random forest. No associations were found when using sleep dimensions or LCA. Overall, findings observed in PWH were similar to those seen in HIV-negative individuals (median age 61 years, 67% males). CONCLUSIONS: Using multivariable analytical approaches, measures of sleep continuity, timing and regularity were associated with cognitive performance in PWH, supporting the utility of newer methods of incorporating multiple standard and novel measures of sleep-wake patterns in assessment of health and functioning. © Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society.
STUDY OBJECTIVES: We investigated associations between actigraphy-assessed sleep measures and cognitive function in people with and without HIV using different analytical approaches to better understand these associations and highlight differences in results obtained by these approaches. METHODS: Cognitive and 7-day/night actigraphy data were collected from people with HIV (PWH ) and lifestyle-similar HIV-negative individuals from HIV and sexual health clinics in UK/Ireland. A global cognitive T-score was obtained averaging the standardized individual cognitive test scores accounting for socio-demographics. Average and standard deviation (SD) of eleven sleep measures over 7-days/nights were obtained. Rank regression, partial least-squares (PLS ) regression, random forest, sleep dimension construct, and latent class analysis (LCA) were applied to evaluate associations between global T-scores and sleep measures. RESULTS: In 344 PWH (median age 57 years, 86% males), average sleep duration, efficiency and wake after sleep onset were not associated with global T-scores according to rank regression (p=0.51, p=0.09, p=0.16, respectively). In contrast, global T-scores associated with average and SD of length of nocturnal awakenings, SD of maintenance efficiency and average out-of-bed time when analyzed by PLS regression and random forest. No associations were found when using sleep dimensions or LCA. Overall, findings observed in PWH were similar to those seen in HIV-negative individuals (median age 61 years, 67% males). CONCLUSIONS: Using multivariable analytical approaches, measures of sleep continuity, timing and regularity were associated with cognitive performance in PWH , supporting the utility of newer methods of incorporating multiple standard and novel measures of sleep-wake patterns in assessment of health and functioning. © Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society.
Entities: Chemical
Disease
Gene
Species
Keywords:
HIV; cognition; machine learning; sleep; sleep quality
Year: 2021
PMID： 33592094 DOI： 10.1093/sleep/zsab035
Source DB: PubMed Journal: Sleep ISSN： 0161-8105 Impact factor: 5.849