| Literature DB >> 33589833 |
Jérôme Wahis1,2, Angel Baudon1, Ferdinand Althammer3, Damien Kerspern1, Stéphanie Goyon1, Daisuke Hagiwara4, Arthur Lefevre1,4, Lara Barteczko4, Benjamin Boury-Jamot5, Benjamin Bellanger1, Marios Abatis5, Miriam Da Silva Gouveia6, Diego Benusiglio4, Marina Eliava4, Andrei Rozov7, Ivan Weinsanto1, Hanna Sophie Knobloch-Bollmann8,9, Matthew K Kirchner3, Ranjan K Roy3, Hong Wang10,11, Marie Pertin12, Perrine Inquimbert1, Claudia Pitzer13, Jan Siemens10, Yannick Goumon1, Benjamin Boutrel5, Christophe Maurice Lamy14, Isabelle Decosterd12,15, Jean-Yves Chatton12, Nathalie Rouach16, W Scott Young17, Javier E Stern3, Pierrick Poisbeau1, Ron Stoop5, Pascal Darbon1, Valery Grinevich18, Alexandre Charlet19,20.
Abstract
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.Entities:
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Year: 2021 PMID： 33589833 DOI： 10.1038/s41593-021-00800-0
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 28.771