Ruixue Hou1, Shelley A Cole2, Mariaelisa Graff3, Yujie Wang3, Karin Haack2, Sandra Laston4, Nitesh R Mehta5, Roman J Shypailo5, Margaret L Gourlay6, Anthony G Comuzzie7, Kari E North3, Nancy F Butte5, Venkata Saroja Voruganti8. 1. Department of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, 500 Laureate Way, Kannapolis, NC, 28081, USA. 2. Texas Biomedical Research Institute, San Antonio, TX, USA. 3. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 4. South Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas of the Rio Grande Valley, Brownsville, TX, USA. 5. USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. 6. Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 7. The Obesity Society, Silver Spring, MD, USA. 8. Department of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, 500 Laureate Way, Kannapolis, NC, 28081, USA. saroja@unc.edu.
Abstract
BACKGROUND: Our aim was to investigate if moderate to vigorous physical activity (MVPA), calcium intake interacts with bone mineral density (BMD)-related single nucleotide polymorphisms (SNPs) to influence BMD in 750 Hispanic children (4-19y) of the cross-sectional Viva La Familia Study. METHODS: Physical activity and dietary intake were measured by accelerometers and multiple-pass 24 h dietary recalls, respectively. Total body and lumbar spine BMD were measured by dual energy X-ray absorptiometry. A polygenic risk score (PRS) was computed based on SNPs identified in published literature. Regression analysis was conducted with PRSs, MVPA and calcium intake with total body and lumbar spine BMD. RESULTS: We found evidence of statistically significant interaction effects between the PRS and MVPA on total body BMD and lumbar spine BMD (p < 0.05). Higher PRS was associated with a lower total body BMD (β = - 0.040 ± 0.009, p = 1.1 × 10- 5) and lumbar spine BMD (β = - 0.042 ± 0.013, p = 0.0016) in low MVPA group, as compared to high MVPA group (β = - 0.015 ± 0.006, p = 0.02; β = 0.008 ± 0.01, p = 0.4, respectively). DISCUSSION: The study indicated that calcium intake does not modify the relationship between genetic variants and BMD, while it implied physical activity interacts with genetic variants to affect BMD in Hispanic children. Due to limited sample size of our study, future research on gene by environment interaction on bone health and functional studies to provide biological insights are needed. CONCLUSIONS: Bone health in Hispanic children with high genetic risk for low BMD is benefitted more by MVPA than children with low genetic risk. Our results may be useful to predict disease risk and tailor dietary and physical activity advice delivery to people, especially children.
BACKGROUND: Our aim was to investigate if moderate to vigorous physical activity (MVPA), calcium intake interacts with bone mineral density (BMD)-related single nucleotide polymorphisms (SNPs) to influence BMD in 750 Hispanic children (4-19y) of the cross-sectional Viva La Familia Study. METHODS: Physical activity and dietary intake were measured by accelerometers and multiple-pass 24 h dietary recalls, respectively. Total body and lumbar spine BMD were measured by dual energy X-ray absorptiometry. A polygenic risk score (PRS) was computed based on SNPs identified in published literature. Regression analysis was conducted with PRSs, MVPA and calcium intake with total body and lumbar spine BMD. RESULTS: We found evidence of statistically significant interaction effects between the PRS and MVPA on total body BMD and lumbar spine BMD (p < 0.05). Higher PRS was associated with a lower total body BMD (β = - 0.040 ± 0.009, p = 1.1 × 10- 5) and lumbar spine BMD (β = - 0.042 ± 0.013, p = 0.0016) in low MVPA group, as compared to high MVPA group (β = - 0.015 ± 0.006, p = 0.02; β = 0.008 ± 0.01, p = 0.4, respectively). DISCUSSION: The study indicated that calcium intake does not modify the relationship between genetic variants and BMD, while it implied physical activity interacts with genetic variants to affect BMD in Hispanic children. Due to limited sample size of our study, future research on gene by environment interaction on bone health and functional studies to provide biological insights are needed. CONCLUSIONS: Bone health in Hispanic children with high genetic risk for low BMD is benefitted more by MVPA than children with low genetic risk. Our results may be useful to predict disease risk and tailor dietary and physical activity advice delivery to people, especially children.
Authors: Jonathan A Mitchell; Alessandra Chesi; Okan Elci; Shana E McCormack; Sani M Roy; Heidi J Kalkwarf; Joan M Lappe; Vicente Gilsanz; Sharon E Oberfield; John A Shepherd; Andrea Kelly; Struan Fa Grant; Babette S Zemel Journal: J Bone Miner Res Date: 2016-08 Impact factor: 6.741
Authors: Nancy F Butte; Guowen Cai; Shelley A Cole; Theresa A Wilson; Jennifer O Fisher; Issa F Zakeri; Kenneth J Ellis; Anthony G Comuzzie Journal: Am J Clin Nutr Date: 2007-06 Impact factor: 7.045
Authors: Ruixue Hou; Shelley A Cole; Mariaelisa Graff; Karin Haack; Sandra Laston; Anthony G Comuzzie; Nitesh R Mehta; Kathleen Ryan; Diana L Cousminer; Babette S Zemel; Struan F A Grant; Braxton D Mitchell; Roman J Shypailo; Margaret L Gourlay; Kari E North; Nancy F Butte; V Saroja Voruganti Journal: Bone Date: 2019-11-29 Impact factor: 4.398