Literature DB >> 33588433

Oral Immunotherapy With Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection.

Estelle F Chiari1, William Weiss2, Michael R Simon1,3,4,5, Stephan T Kiessig6, Mark Pulse2, Stephen C Brown1, Hanne R Gerding6, Maurice Mandago6, Karina Gisch7, Christoph von Eichel-Streiber7.   

Abstract

Coadministration of human secretory IgA (sIgA) together with subtherapeutic vancomycin enhanced survival in the Clostridioides difficile infection (CDI) hamster model. Vancomycin (5 or 10 mg/kg × 5 days) plus healthy donor plasma sIgA/monomeric IgA (TID × 21 days) or hyperimmune sIgA/monomeric IgA (BID × 13 days) enhanced survival. Survival was improved compared to vancomycin alone, P = .018 and .039 by log-rank Mantel-Cox, for healthy and hyperimmune sIgA, respectively. Passive immunization with sIgA (recombinant human secretory component plus IgA dimer/polymer from pooled human plasma) can be administered orally and prevents death in a partially treated CDI hamster model.
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  zzm321990 Clostridioides difficile infection; immunotherapy; secretory IgA

Mesh：

Substances：

Year:  2021        PMID： 33588433      PMCID： PMC8557658          DOI： 10.1093/infdis/jiab087

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  12 in total

1.  Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo.

Authors:  Armelle Phalipon; Ana Cardona; Jean Pierre Kraehenbuhl; Léna Edelman; Philippe J Sansonetti; Blaise Corthésy
Journal:  Immunity       Date:  2002-07       Impact factor: 31.745

2.  Preparation and properties of serum and plasma proteins; a system for the separation into fractions of the protein and lipoprotein components of biological tissues and fluids.

Authors:  E J COHN; L E STRONG
Journal:  J Am Chem Soc       Date:  1946-03       Impact factor: 15.419

3.  The Use of Solvent/Detergent Treatment in Pathogen Reduction of Plasma.

Authors:  Peter Hellstern; Bjarte G Solheim
Journal:  Transfus Med Hemother       Date:  2011-01-17       Impact factor: 3.747

4.  Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A.

Authors:  L Kyne; M Warny; A Qamar; C P Kelly
Journal:  N Engl J Med       Date:  2000-02-10       Impact factor: 91.245

Review 5.  Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut.

Authors:  N J Mantis; N Rol; B Corthésy
Journal:  Mucosal Immunol       Date:  2011-10-05       Impact factor: 7.313

6.  Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin.

Authors:  D Y Leung; C P Kelly; M Boguniewicz; C Pothoulakis; J T LaMont; A Flores
Journal:  J Pediatr       Date:  1991-04       Impact factor: 4.406

7.  Immunoglobulin G directed against toxins A and B of Clostridium difficile in the general population and patients with antibiotic-associated diarrhea.

Authors:  A E Bacon; R Fekety
Journal:  Diagn Microbiol Infect Dis       Date:  1994-04       Impact factor: 2.803

8.  Induction of antitoxin responses in Clostridium-difficile-infected patients compared to healthy blood donors.

Authors:  Alice von Eichel-Streiber; Wonbeom Paik; Katherine Knight; Karina Gisch; Karolina Nadjafi; Christine Decker; Oliver Bosnjak; Adam Cheknis; Stuart Johnson; Christoph von Eichel-Streiber
Journal:  Anaerobe       Date:  2016-07-15       Impact factor: 3.331

Review 9.  Jacalin: a jackfruit (Artocarpus heterophyllus) seed-derived lectin of versatile applications in immunobiological research.

Authors:  S Kabir
Journal:  J Immunol Methods       Date:  1998-03-15       Impact factor: 2.303

Review 10.  Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial Cells.

Authors:  Bernadeta Pietrzak; Katarzyna Tomela; Agnieszka Olejnik-Schmidt; Andrzej Mackiewicz; Marcin Schmidt
Journal:  Int J Mol Sci       Date:  2020-12-04       Impact factor: 5.923
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1.  Promoting intestinal IgA production in mice by oral administration with anthocyanins.

Authors:  Xuerun Liu; Luoyang Wang; Huiren Zhuang; Zhenghuan Yang; Guoqiang Jiang; Zheng Liu
Journal:  Front Immunol       Date:  2022-07-27       Impact factor: 8.786

Review 2.  Application of recombinant antibodies for treatment of Clostridioides difficile infection: Current status and future perspective.

Authors:  Hamideh Raeisi; Masoumeh Azimirad; Ali Nabavi-Rad; Hamid Asadzadeh Aghdaei; Abbas Yadegar; Mohammad Reza Zali
Journal:  Front Immunol       Date:  2022-08-23       Impact factor: 8.786
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