Yijun Yang1, Justin Kurian2, Giana Schena1, Jaslyn Johnson1, Hajime Kubo1, Joshua G Travers3, Chunya Kang4, Anna Maria Lucchese5, Deborah M Eaton1, Maoting Lv6, Na Li7, Lorianna G Leynes8, Daohai Yu9, Fengzhen Yang7, Timothy A McKinsey3, Raj Kishore5, Mohsin Khan2, Sadia Mohsin10, Steven R Houser1. 1. Independence Blue Cross Cardiovascular Research Center and Department of Physiology (Y.Y., G.S., J.J., H.K., D.M.E., S.R.H.). 2. Center for Metabolic Disease Research and Department of Physiology (J.K., M.K.) at Temple University, Philadelphia, PA. 3. Department of Medicine, Division of Cardiology, and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora (J.G.T., T.A.M.). 4. Medical University of Lublin, Poland (C.K.). 5. Center for Translational Medicine (A.M.L., R.K.) at Temple University, Philadelphia, PA. 6. Second Ultrasound Department (M.L.). 7. Second Department of Obstetrics, Cangzhou Central Hospital, Hebei, China (N.L., F.Y.). 8. Lewis Katz School of Medicine (L.G.L.) at Temple University, Philadelphia, PA. 9. Department of Clinical Sciences (D.Y.) at Temple University, Philadelphia, PA. 10. Independence Blue Cross Cardiovascular Research Center and Department of Pharmacology (S.M.) at Temple University, Philadelphia, PA.
Abstract
BACKGROUND: The heart undergoes physiological hypertrophy during pregnancy in healthy individuals. Metabolic syndrome (MetS) is now prevalent in women of child-bearing age and might add risks of adverse cardiovascular events during pregnancy. The present study asks if cardiac remodeling during pregnancy in obese individuals with MetS is abnormal and whether this predisposes them to a higher risk for cardiovascular disorders. METHODS: The idea that MetS induces pathological cardiac remodeling during pregnancy was studied in a long-term (15 weeks) Western diet-feeding animal model that recapitulated features of human MetS. Pregnant female mice with Western diet (45% kcal fat)-induced MetS were compared with pregnant and nonpregnant females fed a control diet (10% kcal fat). RESULTS: Pregnant mice fed a Western diet had increased heart mass and exhibited key features of pathological hypertrophy, including fibrosis and upregulation of fetal genes associated with pathological hypertrophy. Hearts from pregnant animals with WD-induced MetS had a distinct gene expression profile that could underlie their pathological remodeling. Concurrently, pregnant female mice with MetS showed more severe cardiac hypertrophy and exacerbated cardiac dysfunction when challenged with angiotensin II/phenylephrine infusion after delivery. CONCLUSIONS: These results suggest that preexisting MetS could disrupt physiological hypertrophy during pregnancy to produce pathological cardiac remodeling that could predispose the heart to chronic disorders.
BACKGROUND: The heart undergoes physiological hypertrophy during pregnancy in healthy individuals. Metabolic syndrome (MetS) is now prevalent in women of child-bearing age and might add risks of adverse cardiovascular events during pregnancy. The present study asks if cardiac remodeling during pregnancy in obese individuals with MetS is abnormal and whether this predisposes them to a higher risk for cardiovascular disorders. METHODS: The idea that MetS induces pathological cardiac remodeling during pregnancy was studied in a long-term (15 weeks) Western diet-feeding animal model that recapitulated features of human MetS. Pregnant female mice with Western diet (45% kcal fat)-induced MetS were compared with pregnant and nonpregnant females fed a control diet (10% kcal fat). RESULTS: Pregnant mice fed a Western diet had increased heart mass and exhibited key features of pathological hypertrophy, including fibrosis and upregulation of fetal genes associated with pathological hypertrophy. Hearts from pregnant animals with WD-induced MetS had a distinct gene expression profile that could underlie their pathological remodeling. Concurrently, pregnant female mice with MetS showed more severe cardiac hypertrophy and exacerbated cardiac dysfunction when challenged with angiotensin II/phenylephrine infusion after delivery. CONCLUSIONS: These results suggest that preexisting MetS could disrupt physiological hypertrophy during pregnancy to produce pathological cardiac remodeling that could predispose the heart to chronic disorders.
Authors: Lilach O Lerman; Theodore W Kurtz; Rhian M Touyz; David H Ellison; Alejandro R Chade; Steven D Crowley; David L Mattson; John J Mullins; Jeffrey Osborn; Alfonso Eirin; Jane F Reckelhoff; Costantino Iadecola; Thomas M Coffman Journal: Hypertension Date: 2019-06 Impact factor: 10.190
Authors: Kyle L Fulghum; Juliette B Smith; Julia Chariker; Lauren F Garrett; Kenneth R Brittian; Pawel K Lorkiewicz; Lindsey A McNally; Shizuka Uchida; Steven P Jones; Bradford G Hill; Helen E Collins Journal: Am J Physiol Heart Circ Physiol Date: 2022-05-27 Impact factor: 5.125
Authors: Deborah M Eaton; Remus M Berretta; Jacqueline E Lynch; Joshua G Travers; Ryan D Pfeiffer; Michelle L Hulke; Huaqing Zhao; Alexander R H Hobby; Giana Schena; Jaslyn P Johnson; Markus Wallner; Edward Lau; Maggie P Y Lam; Kathleen C Woulfe; Nathan R Tucker; Timothy A McKinsey; Marla R Wolfson; Steven R Houser Journal: Am J Physiol Heart Circ Physiol Date: 2022-09-02 Impact factor: 5.125