Literature DB >> 3358736

Penetration of topically applied dexamethasone alcohol into human aqueous humor.

D Watson1, M J Noble, G N Dutton, J M Midgley, T M Healey.   

Abstract

Gas chromatography combined with mass spectrometry was used to determine the absorption of topically applied dexamethasone alcohol into the aqueous humor of human subjects undergoing routine intraocular surgery. The dexamethasone concentration in aqueous humor was greatest in the interval between 91 and 120 minutes following instillation (mean concentration, 31 ng/mL). Dexamethasone was still detectable in the aqueous 12 hours after instillation.

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Year:  1988        PMID： 3358736     DOI： 10.1001/archopht.1988.01060130748037

Source DB:  PubMed          Journal:  Arch Ophthalmol        ISSN： 0003-9950


  8 in total

Review 1.  Locally administered ocular corticosteroids: benefits and risks.

Authors:  Charles N J McGhee; Simon Dean; Helen Danesh-Meyer
Journal:  Drug Saf       Date:  2002       Impact factor: 5.606

Review 2.  Pharmacokinetics of ophthalmic corticosteroids.

Authors:  C N McGhee
Journal:  Br J Ophthalmol       Date:  1992-11       Impact factor: 4.638

3.  Two clinical trials of an intraocular steroid delivery system for cataract surgery.

Authors:  D F Chang; V Wong
Journal:  Trans Am Ophthalmol Soc       Date:  1999

Review 4.  [Pharmacokinetics of systemic, regional and topical drugs for therapy of intraocular inflammation].

Authors:  M D Becker; S Lortz; B Flückiger; V Luginbuehl
Journal:  Ophthalmologe       Date:  2014-02       Impact factor: 1.059

5.  Reduced Posology of an Ophthalmic Hydrogel Containing Dexamethasone/Netilmicin to Prevent and Treat Ocular Inflammation After Cataract Surgery: Efficacy and Tolerability.

Authors:  Rita Mencucci; Thomas Ach; Anja Liekfeld; Antonio Scialdone; Claudine Civiale; Maria Grazia Mazzone; Aldo Caporossi
Journal:  Adv Ther       Date:  2022-10-07       Impact factor: 4.070

6.  Corticosteroid eyedrops induced blepharoptosis and atrophy of levator muscle.

Authors:  Xiao Zhang; Mei-Fen Zhang; Da-Chun Zhao; Xiao-Wei Liu
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2020-02-15       Impact factor: 3.117

7.  Effect of dexamethasone 0.1% and prednisolone acetate 1.0% eye drops on the blood-aqueous barrier after cataract surgery: a controlled randomized fluorophotometric study.

Authors:  M Diestelhorst; F Aspacher; W Konen; G K Krieglstein; R D Hilgers
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1992       Impact factor: 3.117

8.  Penetration of topically administered dexamethasone disodium phosphate and prednisolone acetate into the normal equine ocular fluids.

Authors:  Hanneke Hermans; Els M H van den Berg; Inge J M Slenter; Dax J C Vendrig; Lilian J L de Nijs-Tjon; Johannes C M Vernooij; Harold Brommer; Michael H Boevé; Ronette Gehring
Journal:  Equine Vet J       Date:  2021-11-21       Impact factor: 2.692
  8 in total

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