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Literature DB >> 33585519

Commentary: Antifibrotics in COVID-19 Lung Disease: Let Us Stay Focused.

Soroush Seifirad¹, Lance Alquran¹.

Abstract

Entities: CellLine Chemical Disease Gene Species

Keywords: ARDS; COVID-19; Pirfenidone; antifibrotics; fibrosis

Year: 2021 PMID： 33585519 PMCID： PMC7874198 DOI： 10.3389/fmed.2020.625440

Source DB: PubMed Journal: Front Med (Lausanne) ISSN： 2296-858X

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27 in total

1. Oral pirfenidone protects against fibrosis by inhibiting fibroblast proliferation and TGF-β signaling in a murine colitis model.

Authors: Guanwei Li; Jianan Ren; Qiongyuan Hu; Youming Deng; Guopu Chen; Kun Guo; Ranran Li; Yuan Li; Lei Wu; Gefei Wang; Guosheng Gu; Jieshou Li
Journal: Biochem Pharmacol Date: 2016-08-04 Impact factor: 5.858

2. Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts.

Authors: Enrico Conte; Elisa Gili; Evelina Fagone; Mary Fruciano; Maria Iemmolo; Carlo Vancheri
Journal: Eur J Pharm Sci Date: 2014-03-12 Impact factor: 4.384

3. Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity.

Authors: Jeffrey W Card; William J Racz; James F Brien; Solomon B Margolin; Thomas E Massey
Journal: Toxicol Sci Date: 2003-06-27 Impact factor: 4.849

Commentary: Antifibrotics in COVID-19 Lung Disease: Let Us Stay Focused.

1. Oral pirfenidone protects against fibrosis by inhibiting fibroblast proliferation and TGF-β signaling in a murine colitis model.

2. Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts.

3. Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity.

4. Effect of pirfenidone against vanadate-induced kidney fibrosis in rats.

5. Effects of pirfenidone on the generation of reactive oxygen species in vitro.

6. Effect of pirfenidone on pulmonary fibrosis due to paraquat poisoning in rats.

7. Pirfenidone: A novel hypothetical treatment for COVID-19.

8. Antifibrotics in COVID-19 Lung Disease: Let Us Stay Focused.

Review 1. Acute respiratory distress syndrome in COVID-19: possible mechanisms and therapeutic management.

Review 2. The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy.