Neal Bhatia1,2,3,4, Leon H Kircik1,2,3,4, Ava Shamban1,2,3,4, Varsha Bhatt1,2,3,4, Radhakrishnan Pillai1,2,3,4, Eric Guenin1,2,3,4. 1. Dr. Bhatia is with Therapeutics Clinical Research in San Diego, California. 2. Dr. Kircik is with Indiana University School of Medicine in Indianapolis, IN, Physicians Skin Care, PLLC, in Louisville, Kentucky, and Icahn School of Medicine at Mount Sinai in New York, New York. 3. Dr. Shamban is with AVA MD Santa Monica, Medical and Cosmetic Dermatology in Santa Monica, California. 4. Drs. Bhatt and Pillai are with Bausch Health US, LLC, in Petaluma, California. Dr. Guenin is with Ortho Dermatologics in Bridgewater, New Jersey.
Abstract
OBJECTIVE: This study was conducted to assess compatibility of tretinoin 0.05% acne lotion with foundation makeup. DESIGN: This was a single-center, evaluator-blinded, randomized, controlled clinical trial. Participants were randomized to apply tretinoin 0.05% lotion to either the right or left side of the face before applying full-face foundation makeup. SETTING:Participants were enrolled at a single center in the United States. PARTICIPANTS: Female individuals aged 18 to 50 years who used facial foundation makeup ≥5 days per week were included. MEASUREMENTS: Investigator-assessed grading for foundation coverage and participant evaluations of makeup appearance were conducted at post-makeup application (Post-Makeup) and Hour 6 (6H) timepoints. Antera 3D® images were taken for skin texture roughness analysis and tolerability evaluations were performed at baseline, post-tretinoin application, Post-Makeup, and 6H timepoints. RESULTS:A total of 30 participants were enrolled and 29 completed the study. There were no significant differences between tretinoin treated and untreated sides for any outcomes of investigator-assessed grading of foundation (percentage coverage, blotchiness, overall coverage, skin tone evenness, visual smoothness). There was a small but statistically significant worsening in percent coverage at 6H versus Post-Makeup on the untreated side, but not the treated side. As rated by participants, even/full coverage and skin smoothness were significantly better on the tretinoin-lotion treated versus the untreated side. Three-dimensional imaging showed there were no significant differences in skin roughness between the treated and untreated sides. Participants reported overall satisfaction with the tretinoin lotion-treated side. CONCLUSION:Tretinoin 0.05% lotion did not interfere with facial makeup application or wearability and was well tolerated.
RCT Entities:
OBJECTIVE: This study was conducted to assess compatibility of tretinoin 0.05% acne lotion with foundation makeup. DESIGN: This was a single-center, evaluator-blinded, randomized, controlled clinical trial. Participants were randomized to apply tretinoin 0.05% lotion to either the right or left side of the face before applying full-face foundation makeup. SETTING:Participants were enrolled at a single center in the United States. PARTICIPANTS: Female individuals aged 18 to 50 years who used facial foundation makeup ≥5 days per week were included. MEASUREMENTS: Investigator-assessed grading for foundation coverage and participant evaluations of makeup appearance were conducted at post-makeup application (Post-Makeup) and Hour 6 (6H) timepoints. Antera 3D® images were taken for skin texture roughness analysis and tolerability evaluations were performed at baseline, post-tretinoin application, Post-Makeup, and 6H timepoints. RESULTS: A total of 30 participants were enrolled and 29 completed the study. There were no significant differences between tretinoin treated and untreated sides for any outcomes of investigator-assessed grading of foundation (percentage coverage, blotchiness, overall coverage, skin tone evenness, visual smoothness). There was a small but statistically significant worsening in percent coverage at 6H versus Post-Makeup on the untreated side, but not the treated side. As rated by participants, even/full coverage and skin smoothness were significantly better on the tretinoin-lotion treated versus the untreated side. Three-dimensional imaging showed there were no significant differences in skin roughness between the treated and untreated sides. Participants reported overall satisfaction with the tretinoin lotion-treated side. CONCLUSION:Tretinoin 0.05% lotion did not interfere with facial makeup application or wearability and was well tolerated.
Authors: Jerry K L Tan; Yudi Li; Karen Fung; Aditya K Gupta; D Richard Thomas; Sheetal Sapra; Charles Lynde; Yves Poulin; Wayne Gulliver; Rolf J Sebaldt Journal: J Cutan Med Surg Date: 2008 Sep-Oct Impact factor: 2.092
Authors: Emil A Tanghetti; Linda Stein Gold; James Q Del Rosso; Tina Lin; Arturo Angel; Radhakrishnan Pillai Journal: J Dermatolog Treat Date: 2019-09-26 Impact factor: 3.359