| Literature DB >> 33584664 |
Jeu Park1,2,3, Jee Hyung Sohn1,2,3, Sang Mun Han1,2,3, Yoon Jeong Park1,2,3, Jin Young Huh1,2,3, Sung Sik Choe1,2,3, Jae Bum Kim1,2,3.
Abstract
Accumulating evidence reveals that adipose tissue is an immunologically active organ that exerts multiple impacts on the regulation of systemic energy metabolism. Adipose tissue immunity is modulated by the interactions between adipocytes and various immune cells. Nevertheless, the underlying mechanisms that control inter-cellular interactions between adipocytes and immune cells in adipose tissue have not been thoroughly elucidated. Recently, it has been demonstrated that adipocytes utilize lipid metabolites as a key mediator to initiate and mediate diverse adipose tissue immune responses. Adipocytes present lipid antigens and secrete lipid metabolites to determine adipose immune tones. In addition, the interactions between adipocytes and adipose immune cells are engaged in the control of adipocyte fate and functions upon metabolic stimuli. In this review, we discuss an integrated view of how adipocytes communicate with adipose immune cells using lipid metabolites. Also, we briefly discuss the newly discovered roles of adipose stem cells in the regulation of adipose tissue immunity.Entities:
Keywords: adipocytes; adipose tissue inflammation; adipose tissue remodeling; invariant natural killer cell; lipid metabolite
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Year: 2021 PMID： 33584664 PMCID： PMC7876236 DOI： 10.3389/fimmu.2020.598566
Source DB: PubMed Journal: Front Immunol ISSN： 1664-3224 Impact factor: 7.561