Literature DB >> 33583639

The role of immune-mediated alterations and disorders in ALS disease.

João Rodrigues Lima-Junior1, David Sulzer2, Cecilia S Lindestam Arlehamn1, Alessandro Sette3.   

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that leads to neuronal death in the brain and spinal cord. Over the last decades, evidence has emerged regarding the functional diversity of astrocytes, microglia, and T cells in the central nervous system (CNS), and the role of neuroinflammation in ALS. In this review, we summarize current knowledge regarding neuroinflammation in ALS, both at the level of specific molecular pathways and potential cellular pathways as well as outline questions about the immune mechanisms involved in ALS pathogenesis.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  ALS; Autoimmunity; Glial cells; Neuroinflammation

Mesh：

Year:  2021        PMID： 33583639      PMCID： PMC7942756          DOI： 10.1016/j.humimm.2021.01.017

Source DB:  PubMed          Journal:  Hum Immunol        ISSN： 0198-8859            Impact factor:   2.850


  91 in total

1.  A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis.

Authors:  Marcel Maier; Tobias Welt; Fabian Wirth; Fabio Montrasio; Daniel Preisig; Jordan McAfoose; Fernando G Vieira; Luka Kulic; Claudia Späni; Thilo Stehle; Steve Perrin; Markus Weber; Christoph Hock; Roger M Nitsch; Jan Grimm
Journal:  Sci Transl Med       Date:  2018-12-05       Impact factor: 17.956

2.  A robust, good manufacturing practice-compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy.

Authors:  Abdullah Alsuliman; Stanley H Appel; David R Beers; Rafet Basar; Hila Shaim; Indresh Kaur; Jane Zulovich; Eric Yvon; Muharrem Muftuoglu; Nobuhiko Imahashi; Kayo Kondo; Enli Liu; Elizabeth J Shpall; Katayoun Rezvani
Journal:  Cytotherapy       Date:  2016-08-03       Impact factor: 5.414

3.  Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: specificity, sensitivity, and a possible prognostic value.

Authors:  Yu-Ichi Noto; Kazumoto Shibuya; Yasunori Sato; Kazuaki Kanai; Sonoko Misawa; Setsu Sawai; Masahiro Mori; Tomoyuki Uchiyama; Sagiri Isose; Saiko Nasu; Yukari Sekiguchi; Yumi Fujimaki; Takashi Kasai; Takahiko Tokuda; Masanori Nakagawa; Satoshi Kuwabara
Journal:  Amyotroph Lateral Scler       Date:  2010-12-02

4.  Widespread Tau-Specific CD4 T Cell Reactivity in the General Population.

Authors:  Cecilia S Lindestam Arlehamn; John Pham; Roy N Alcalay; April Frazier; Evan Shorr; Chelsea Carpenter; John Sidney; Rekha Dhanwani; Julian Agin-Liebes; Francesca Garretti; Amy W Amara; David G Standaert; Elizabeth J Phillips; Simon A Mallal; Bjoern Peters; David Sulzer; Alessandro Sette
Journal:  J Immunol       Date:  2019-05-13       Impact factor: 5.422

5.  T cell receptor BV gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic lateral sclerosis.

Authors:  M A Panzara; E Gussoni; A B Begovich; R S Murray; Y Q Zang; S H Appel; L Steinman; J Zhang
Journal:  Neurobiol Dis       Date:  1999-10       Impact factor: 5.996

6.  Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2.

Authors:  Yang Liu; Wenlin Hao; Alik Dawson; Shirong Liu; Klaus Fassbender
Journal:  J Biol Chem       Date:  2008-12-17       Impact factor: 5.157

7.  Exosome secretion is a key pathway for clearance of pathological TDP-43.

Authors:  Yohei Iguchi; Lara Eid; Martin Parent; Geneviève Soucy; Christine Bareil; Yuichi Riku; Kaori Kawai; Shinnosuke Takagi; Mari Yoshida; Masahisa Katsuno; Gen Sobue; Jean-Pierre Julien
Journal:  Brain       Date:  2016-09-27       Impact factor: 13.501

8.  A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Authors:  Alan E Renton; Elisa Majounie; Adrian Waite; Javier Simón-Sánchez; Sara Rollinson; J Raphael Gibbs; Jennifer C Schymick; Hannu Laaksovirta; John C van Swieten; Liisa Myllykangas; Hannu Kalimo; Anders Paetau; Yevgeniya Abramzon; Anne M Remes; Alice Kaganovich; Sonja W Scholz; Jamie Duckworth; Jinhui Ding; Daniel W Harmer; Dena G Hernandez; Janel O Johnson; Kin Mok; Mina Ryten; Danyah Trabzuni; Rita J Guerreiro; Richard W Orrell; James Neal; Alex Murray; Justin Pearson; Iris E Jansen; David Sondervan; Harro Seelaar; Derek Blake; Kate Young; Nicola Halliwell; Janis Bennion Callister; Greg Toulson; Anna Richardson; Alex Gerhard; Julie Snowden; David Mann; David Neary; Michael A Nalls; Terhi Peuralinna; Lilja Jansson; Veli-Matti Isoviita; Anna-Lotta Kaivorinne; Maarit Hölttä-Vuori; Elina Ikonen; Raimo Sulkava; Michael Benatar; Joanne Wuu; Adriano Chiò; Gabriella Restagno; Giuseppe Borghero; Mario Sabatelli; David Heckerman; Ekaterina Rogaeva; Lorne Zinman; Jeffrey D Rothstein; Michael Sendtner; Carsten Drepper; Evan E Eichler; Can Alkan; Ziedulla Abdullaev; Svetlana D Pack; Amalia Dutra; Evgenia Pak; John Hardy; Andrew Singleton; Nigel M Williams; Peter Heutink; Stuart Pickering-Brown; Huw R Morris; Pentti J Tienari; Bryan J Traynor
Journal:  Neuron       Date:  2011-09-21       Impact factor: 17.173

Review 9.  Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors.

Authors:  Yang Yang; Huanan Wang; Mohammed Kouadir; Houhui Song; Fushan Shi
Journal:  Cell Death Dis       Date:  2019-02-12       Impact factor: 8.469

10.  C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice.

Authors:  Amanda Atanasio; Vilma Decman; Derek White; Meg Ramos; Burcin Ikiz; Hoi-Ching Lee; Chia-Jen Siao; Susannah Brydges; Elizabeth LaRosa; Yu Bai; Wen Fury; Patricia Burfeind; Ralica Zamfirova; Gregg Warshaw; Jamie Orengo; Adelekan Oyejide; Michael Fralish; Wojtek Auerbach; William Poueymirou; Jan Freudenberg; Guochun Gong; Brian Zambrowicz; David Valenzuela; George Yancopoulos; Andrew Murphy; Gavin Thurston; Ka-Man Venus Lai
Journal:  Sci Rep       Date:  2016-03-16       Impact factor: 4.379
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  3 in total

1.  The mechanism of action of a novel neuroprotective low molecular weight dextran sulphate: New platform therapy for neurodegenerative diseases like Amyotrophic Lateral Sclerosis.

Authors:  Ann Logan; Antonio Belli; Valentina Di Pietro; Barbara Tavazzi; Giacomo Lazzarino; Renata Mangione; Giuseppe Lazzarino; Inés Morano; Omar Qureshi; Lars Bruce; Nicholas M Barnes; Zsuzsanna Nagy
Journal:  Front Pharmacol       Date:  2022-08-30       Impact factor: 5.988

Review 2.  Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins.

Authors:  Greta Limoni
Journal:  Int J Mol Sci       Date:  2021-06-06       Impact factor: 5.923

3.  Inhibition of heat shock proteins increases autophagosome formation, and reduces the expression of APP, Tau, SOD1 G93A and TDP-43.

Authors:  Paul Dent; Laurence Booth; Jane L Roberts; Andrew Poklepovic; Derek Cridebring; Eric M Reiman
Journal:  Aging (Albany NY)       Date:  2021-07-12       Impact factor: 5.682
  3 in total

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