Carolina Baeza-Velasco1,2,3, Sonia Lorente4,5, Elisabet Tasa-Vinyals6,7, Sébastien Guillaume8,9, Maria Soledad Mora7, Paola Espinoza7. 1. Laboratoire de Psychopathologie et Processus de Santé, Université de Paris, F-92100, Boulogne-Billacourt, France. carolina.baeza-velasco@u-paris.fr. 2. Department of Emergency Psychiatry and Acute Care, CHU Montpellier, Montpellier, France. carolina.baeza-velasco@u-paris.fr. 3. Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France. carolina.baeza-velasco@u-paris.fr. 4. Department of Psychobiology and Methodology of Health Science, Universitat Autònoma de Barcelona, Cerdanyola, Barcelona, Spain. 5. Paediatric Department, Hospital de Terrassa, Consorci Sanitari de Terrassa, CST, Barcelona, Spain. 6. Department of Psychiatry and Mental Health, Osona Salut Mental. Consorci Hospitalari de Vic, Vic (Barcelona), Catalonia, Spain. 7. Departament de Psicologia, Unitat d'Avaluació i Intervenció en Imatge Corporal, Clínica i de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain. 8. Department of Emergency Psychiatry and Acute Care, CHU Montpellier, Montpellier, France. 9. Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.
Abstract
PURPOSE: Ehlers-Danlos syndromes (EDS) are a group of heritable conditions in which abnormal collagen synthesis leads to features such as joint hypermobility, skin abnormalities, and tissue fragility. Gastrointestinal (GI) symptoms are common among those affected. These may negatively impact eating behaviors, leading to weight/nutritional problems. We aimed to compare GI symptoms, disordered eating, and body mass index (BMI) between EDS patients and healthy controls, and to explore the link between these variables in EDS patients. METHOD: In this cross-sectional study, women with EDS and healthy controls responded to an online survey assessing GI symptoms (heartburn/regurgitations, early satiety, nausea/vomiting, bloating, abdominal pain, dysphagia), food allergies/intolerances, disordered eating, history of eating disorders (ED), and BMI. We performed intergroup comparisons as well as multivariate analyses to explore the associations between disordered eating, GI symptoms, and BMI in the EDS group. RESULTS: Sixty-six women with EDS and 39 healthy controls were included in the study. The EDS patients showed significantly more GI symptoms and food allergies/intolerances, increased prevalence of ED history, higher risk of current ED, and lower BMI than the controls. In the EDS group, the risk for ED was associated with GI symptoms; restricted eating was associated with GI symptoms, food allergies/intolerances, and dysphagia; uncontrolled eating was associated with GI symptoms; and BMI was associated with GI symptoms and food allergies/intolerances. DISCUSSION: Our results are concordant with that of previous reports highlighting the high level of GI problems and disordered eating in women with EDS. In addition, and for the first-time, the association between both is evidenced in this specific population. LEVEL OF EVIDENCE III: Case-control analytic study.
PURPOSE: Ehlers-Danlos syndromes (EDS) are a group of heritable conditions in which abnormal collagen synthesis leads to features such as joint hypermobility, skin abnormalities, and tissue fragility. Gastrointestinal (GI) symptoms are common among those affected. These may negatively impact eating behaviors, leading to weight/nutritional problems. We aimed to compare GI symptoms, disordered eating, and body mass index (BMI) between EDS patients and healthy controls, and to explore the link between these variables in EDS patients. METHOD: In this cross-sectional study, women with EDS and healthy controls responded to an online survey assessing GI symptoms (heartburn/regurgitations, early satiety, nausea/vomiting, bloating, abdominal pain, dysphagia), food allergies/intolerances, disordered eating, history of eating disorders (ED), and BMI. We performed intergroup comparisons as well as multivariate analyses to explore the associations between disordered eating, GI symptoms, and BMI in the EDS group. RESULTS: Sixty-six women with EDS and 39 healthy controls were included in the study. The EDS patients showed significantly more GI symptoms and food allergies/intolerances, increased prevalence of ED history, higher risk of current ED, and lower BMI than the controls. In the EDS group, the risk for ED was associated with GI symptoms; restricted eating was associated with GI symptoms, food allergies/intolerances, and dysphagia; uncontrolled eating was associated with GI symptoms; and BMI was associated with GI symptoms and food allergies/intolerances. DISCUSSION: Our results are concordant with that of previous reports highlighting the high level of GI problems and disordered eating in women with EDS. In addition, and for the first-time, the association between both is evidenced in this specific population. LEVEL OF EVIDENCE III: Case-control analytic study.
Authors: Marco Castori; Brad Tinkle; Howard Levy; Rodney Grahame; Fransiska Malfait; Alan Hakim Journal: Am J Med Genet C Semin Med Genet Date: 2017-02-01 Impact factor: 3.908
Authors: Asma Fikree; Gisela Chelimsky; Heidi Collins; Katcha Kovacic; Qasim Aziz Journal: Am J Med Genet C Semin Med Genet Date: 2017-02-10 Impact factor: 3.908
Authors: Marco Castori; Silvia Morlino; Giulia Pascolini; Carlo Blundo; Paola Grammatico Journal: Am J Med Genet C Semin Med Genet Date: 2015-03 Impact factor: 3.908
Authors: Asma Fikree; Rodney Grahame; Rubina Aktar; Adam D Farmer; Alan J Hakim; Joan K Morris; Charles H Knowles; Qasim Aziz Journal: Clin Gastroenterol Hepatol Date: 2014-01-16 Impact factor: 11.382
Authors: A D Nelson; M A Mouchli; N Valentin; D Deyle; P Pichurin; A Acosta; M Camilleri Journal: Neurogastroenterol Motil Date: 2015-09-16 Impact factor: 3.598
Authors: Carolina Baeza-Velasco; Thomas Van den Bossche; Daniel Grossin; Claude Hamonet Journal: Eat Weight Disord Date: 2015-10-27 Impact factor: 4.652