| Literature DB >> 33582901 |
Meng-Yuan Liang1, Ping Chen1, Miao He1, Jian Tang1, Hui Li1, Xin-Liang He1, Ya-Ya Zhou1, Si-Wei Feng1, Yu-E Xue1, Yao Liu1, Yan-Ling Ma2, Jian-Chu Zhang3.
Abstract
The role of corticosteroids in the treatment of Coronavirus disease 2019 (COVID-19) is controversial. In the present study, we evaluated the effects of adjuvant corticosteroids treatment on the outcome of patients with COVID-19 (n=966), using Propensity Score Matching to adjust for potential differences between the corticosteroids group (n=289) and the non-corticosteroids group (n=677). Analysis of data without adjusting differences in baseline characteristics indicated that the proportion of mechanical ventilation and the mortality was higher in the corticosteroids treatment group in total or severe/critical patients. The duration of viral shedding was longer in the non-corticosteroids treatment group in total or general/mild patients. After adjusting the difference between the corticosteroids and non-corticosteroids treatment group, the analysis revealed that the use of corticosteroids had no effect on the duration of viral shedding, in-hospital mortality or 28-day mortality.Entities:
Keywords: coronavirus disease 2019; corticosteroids; mortality; severe acute respiratory syndrome coronavirus 2; viral shedding
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Year: 2021 PMID： 33582901 PMCID： PMC7881915 DOI： 10.1007/s11596-021-2313-6
Source DB: PubMed Journal: Curr Med Sci ISSN： 2523-899X