Ivan Hc Wu1, Natalia Heredia2, Qiong Dong3, Lorna H McNeill4, Diwakar D Balachandran5, Qian Lu4, Shine Chang3. 1. Department of Health Disparities Research, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address: ihwu@mdanderson.org. 2. Department of Health Promotion & Behavioral Sciences, The University of Texas Health Science Center at Houston, School of Public Health, Houston, Texas, USA. 3. Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 4. Department of Health Disparities Research, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 5. Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Abstract
STUDY OBJECTIVES: The primary aim of the study was to estimate the effect of sleep duration on prospective type 2 diabetes (T2D) risk across demographic characteristics and follow-up periods, and test body mass index (BMI) as a mediator and moderator. METHODS: Data included adults (Mage = 39.0 ± 12.7 years) born in the United States or Mexico recruited from 2001 to 2012 in a Mexican American cohort study conducted in Houston, TX (n = 15,779). Participants completed self-reported questionnaires at baseline related to health, health behaviors (sleep duration, physical activity, smoking, drinking), and sociocultural factors and were followed up annually. RESULTS: Cox proportional hazard models estimated hazard ratios (HR) for the effect of sleep duration on T2D diagnosis at follow-up. Of the participants, 10.3% were diagnosed with T2D. Self-reported ≤5 hours of sleep, compared to 7-8 hours, at baseline predicted greater risk for T2D (HR = 1.32, P = .001), yet was no longer significant after adjusting for sociodemographic characteristics and BMI. Notably, those with BMI <25 kg/m2 reporting ≤5 hours of sleep were at significant risk for T2D at 3 (HR = 4.13, P = .024) and 5-year follow-up (HR = 3.73, P = .008) compared to 7-8 hours. Obesity status accounted for 31.6% and 27.3% of the variance in the association between ≤5 and 6 hours of sleep and increased T2D risk, respectively. CONCLUSIONS: Results highlighted the mediating and moderating role of BMI, and its effect on T2D risk at earlier follow-up among those without obesity. T2D prevention and control for Mexican American adults should consider the role of chronic sleep loss.
STUDY OBJECTIVES: The primary aim of the study was to estimate the effect of sleep duration on prospective type 2 diabetes (T2D) risk across demographic characteristics and follow-up periods, and test body mass index (BMI) as a mediator and moderator. METHODS: Data included adults (Mage = 39.0 ± 12.7 years) born in the United States or Mexico recruited from 2001 to 2012 in a Mexican American cohort study conducted in Houston, TX (n = 15,779). Participants completed self-reported questionnaires at baseline related to health, health behaviors (sleep duration, physical activity, smoking, drinking), and sociocultural factors and were followed up annually. RESULTS: Cox proportional hazard models estimated hazard ratios (HR) for the effect of sleep duration on T2D diagnosis at follow-up. Of the participants, 10.3% were diagnosed with T2D. Self-reported ≤5 hours of sleep, compared to 7-8 hours, at baseline predicted greater risk for T2D (HR = 1.32, P = .001), yet was no longer significant after adjusting for sociodemographic characteristics and BMI. Notably, those with BMI <25 kg/m2 reporting ≤5 hours of sleep were at significant risk for T2D at 3 (HR = 4.13, P = .024) and 5-year follow-up (HR = 3.73, P = .008) compared to 7-8 hours. Obesity status accounted for 31.6% and 27.3% of the variance in the association between ≤5 and 6 hours of sleep and increased T2D risk, respectively. CONCLUSIONS: Results highlighted the mediating and moderating role of BMI, and its effect on T2D risk at earlier follow-up among those without obesity. T2D prevention and control for Mexican American adults should consider the role of chronic sleep loss.
Authors: Wong-Ho Chow; Matthew Chrisman; Carrie R Daniel; Yuanqing Ye; Henry Gomez; Qiong Dong; Chelsea E Anderson; Shine Chang; Sara Strom; Hua Zhao; Xifeng Wu Journal: Int J Epidemiol Date: 2017-04-01 Impact factor: 7.196
Authors: Joseph A Roscoe; Maralyn E Kaufman; Sara E Matteson-Rusby; Oxana G Palesh; Julie L Ryan; Sadhna Kohli; Michael L Perlis; Gary R Morrow Journal: Oncologist Date: 2007
Authors: Ketrell L McWhorter; Yong-Moon Park; Symielle A Gaston; Kacey B Fang; Dale P Sandler; Chandra L Jackson Journal: BMJ Open Diabetes Res Care Date: 2019-09-20