Modeling multivariate clinical event time-series with recurrent temporal mechanisms.

In this work, we propose a novel autoregressive event time-series model that can predict future occurrences of multivariate clinical events. Our model represents multivariate event time-series using different temporal mechanisms aimed to fit different temporal characteristics of the time-series. In particular, information about distant past is modeled through the hidden state space defined by an LSTM-based model, information on recently observed clinical events is modeled through discriminative projections, and information about periodic (repeated) events is modeled using a special recurrent mechanism based on probability distributions of inter-event gaps compiled from past data. We evaluate our proposed model on electronic health record (EHRs) data derived from MIMIC-III dataset. We show that our new model equipped with the above temporal mechanisms leads to improved prediction performance compared to multiple baselines.