Manuel Ester1, S Nicole Culos-Reed1,2,3, Amane Abdul-Razzak4, Julia T Daun1, Delaney Duchek1, George Francis5, Gwyn Bebb2, Jennifer Black6,7, Audra Arlain6, Chelsia Gillis8,9, Lyle Galloway2,10, Lauren C Capozzi11,12. 1. Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. 2. Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. 3. Department of Psychosocial Resources, Tom Baker Cancer Centre, Calgary, Alberta, Canada. 4. Division of Palliative Medicine, Department of Oncology, University of Calgary, Calgary, Alberta, Canada. 5. Division of Physical Medicine and Rehabilitation, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. 6. Cancer Control Alberta, Alberta Health Services, Calgary, Alberta, Canada. 7. Nutrition Services, Foothills Medical Centre, Cancer Care & Alberta Healthy Living Program, Calgary, Alberta, Canada. 8. Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. 9. Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. 10. Department of Family Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. 11. Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. lcapozzi@ucalgary.ca. 12. Division of Physical Medicine and Rehabilitation, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. lcapozzi@ucalgary.ca.
Abstract
BACKGROUND: Advanced lung cancer patients face significant physical and psychological burden leading to reduced physical function and quality of life. Separately, physical activity, nutrition, and palliative symptom management interventions have been shown to improve functioning in this population, however no study has combined all three in a multimodal intervention. Therefore, we assessed the feasibility of a multimodal physical activity, nutrition, and palliative symptom management intervention in advanced lung cancer. METHODS: Participants received an individually tailored 12-week intervention featuring in-person group-based exercise classes, at-home physical activity prescription, behaviour change education, and nutrition and palliative care consultations. Patients reported symptom burden, energy, and fatigue before and after each class. At baseline and post-intervention, symptom burden, quality of life, fatigue, physical activity, dietary intake, and physical function were assessed. Post-intervention interviews examined participant perspectives. RESULTS: The multimodal program was feasible, with 44% (10/23) recruitment, 75% (75/100) class attendance, 89% (8/9) nutrition and palliative consult attendance, and 85% (17/20) assessment completion. Of ten participants, 70% (7/10) completed the post-intervention follow-up. Participants perceived the intervention as feasible and valuable. Physical activity, symptom burden, and quality of life were maintained, while tiredness decreased significantly. Exercise classes prompted acute clinically meaningful reductions in fatigue, tiredness, depression, pain, and increases in energy and well-being. CONCLUSION: A multimodal physical activity, nutrition, and palliative symptom management intervention is feasible and shows potential benefits on quality of life that warrant further investigation in a larger cohort trial. TRIAL REGISTRATION: NCT04575831 , Registered 05 October 2020 - Retrospectively registered.
BACKGROUND: Advanced lung cancerpatients face significant physical and psychological burden leading to reduced physical function and quality of life. Separately, physical activity, nutrition, and palliative symptom management interventions have been shown to improve functioning in this population, however no study has combined all three in a multimodal intervention. Therefore, we assessed the feasibility of a multimodal physical activity, nutrition, and palliative symptom management intervention in advanced lung cancer. METHODS:Participants received an individually tailored 12-week intervention featuring in-person group-based exercise classes, at-home physical activity prescription, behaviour change education, and nutrition and palliative care consultations. Patients reported symptom burden, energy, and fatigue before and after each class. At baseline and post-intervention, symptom burden, quality of life, fatigue, physical activity, dietary intake, and physical function were assessed. Post-intervention interviews examined participant perspectives. RESULTS: The multimodal program was feasible, with 44% (10/23) recruitment, 75% (75/100) class attendance, 89% (8/9) nutrition and palliative consult attendance, and 85% (17/20) assessment completion. Of ten participants, 70% (7/10) completed the post-intervention follow-up. Participants perceived the intervention as feasible and valuable. Physical activity, symptom burden, and quality of life were maintained, while tiredness decreased significantly. Exercise classes prompted acute clinically meaningful reductions in fatigue, tiredness, depression, pain, and increases in energy and well-being. CONCLUSION: A multimodal physical activity, nutrition, and palliative symptom management intervention is feasible and shows potential benefits on quality of life that warrant further investigation in a larger cohort trial. TRIAL REGISTRATION: NCT04575831 , Registered 05 October 2020 - Retrospectively registered.
Entities:
Keywords:
Advanced lung cancer; Exercise oncology; Nutrition; Quality of life; Supportive cancer care; Symptom management
Authors: Camilla Zimmermann; Nadia Swami; Monika Krzyzanowska; Breffni Hannon; Natasha Leighl; Amit Oza; Malcolm Moore; Anne Rydall; Gary Rodin; Ian Tannock; Allan Donner; Christopher Lo Journal: Lancet Date: 2014-02-19 Impact factor: 79.321
Authors: Margaret L McNeely; Christopher Sellar; Tanya Williamson; Melissa Shea-Budgell; Anil Abraham Joy; Harold Y Lau; Jacob C Easaw; Albert D Murtha; Jeffrey Vallance; Kerry Courneya; John R Mackey; Matthew Parliament; Nicole Culos-Reed Journal: BMJ Open Date: 2019-09-13 Impact factor: 2.692
Authors: Julia T Daun; Lauren C Capozzi; Gloria Roldan Urgoiti; Meghan H McDonough; Jacob C Easaw; Margaret L McNeely; George J Francis; Tanya Williamson; Jessica Danyluk; Emma McLaughlin; Paula A Ospina; Marie de Guzman Wilding; Lori Radke; Amy Driga; Christine Lesiuk; S Nicole Culos-Reed Journal: Contemp Clin Trials Commun Date: 2022-05-25