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Literature DB >> 33579377

MiRNA-mediated EMT and CSCs in cancer chemoresistance.

Bing Dong¹, Shiyu Li², Shuangli Zhu², Ming Yi², Suxia Luo³, Kongming Wu^4,5.

Abstract

Cancer stem cells (CSCs) are a small group of cancer cells, which contribute to tumorigenesis and cancer progression. Cancer cells undergoing epithelial-to-mesenchymal transition (EMT) acquire the chemoresistant ability, which is regarded as an important feature of CSCs. Thus, there emerges an opinion that the generation of CSCs is considered to be driven by EMT. In this complex process, microRNAs (miRNAs) are found to play a key role. In order to overcome the drug resistance, inhibiting EMT as well as CSCs phenotype seem feasible. Thereinto, regulating the EMT- or CSCs-associated miRNAs is a crucial approach. Herein, we conduct this review to elaborate on the complicated interplay between EMT and CSCs in cancer chemoresistance, which is modulated by miRNAs. In addition, we elucidate the therapeutic strategy to overcome drug resistance through targeting EMT and CSCs.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: CSCs; Chemoresistance; EMT; miRNA

Year: 2021 PMID： 33579377 PMCID： PMC7881653 DOI： 10.1186/s40164-021-00206-5

Source DB: PubMed Journal: Exp Hematol Oncol ISSN： 2162-3619

129 in total

1. First Axl inhibitor enters clinical trials.

Authors: Cormac Sheridan
Journal: Nat Biotechnol Date: 2013-09 Impact factor: 54.908

2. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis.

Authors: Yan Li; Qiupeng Zheng; Chunyang Bao; Shuyi Li; Weijie Guo; Jiang Zhao; Di Chen; Jianren Gu; Xianghuo He; Shenglin Huang
Journal: Cell Res Date: 2015-07-03 Impact factor: 25.617

3. MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells.

Authors: Nerea Bitarte; Eva Bandres; Valentina Boni; Ruth Zarate; Javier Rodriguez; Marisol Gonzalez-Huarriz; Ines Lopez; Jesus Javier Sola; Marta M Alonso; Puri Fortes; Jesus Garcia-Foncillas
Journal: Stem Cells Date: 2011-11 Impact factor: 6.277

Review 4. IGF1 receptor signaling pathways.

Authors: Fumihiko Hakuno; Shin-Ichiro Takahashi
Journal: J Mol Endocrinol Date: 2018-03-13 Impact factor: 5.098

5. Extracellular vesicles released by mesenchymal-like prostate carcinoma cells modulate EMT state of recipient epithelial-like carcinoma cells through regulation of AR signaling.

Authors: Ihsan Y El-Sayed; Ahmad Daher; Damien Destouches; Virginie Firlej; Enis Kostallari; Pascale Maillé; Eric Huet; Nathaline Haidar-Ahmad; Guido Jenster; Alexandre de la Taille; Raghida Abou Merhi; Stéphane Terry; Francis Vacherot
Journal: Cancer Lett Date: 2017-09-19 Impact factor: 8.679

6. Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells.

Authors: Eva Nievergall; Hayley S Ramshaw; Agnes S M Yong; Mark Biondo; Samantha J Busfield; Gino Vairo; Angel F Lopez; Timothy P Hughes; Deborah L White; Devendra K Hiwase
Journal: Blood Date: 2013-12-20 Impact factor: 22.113

7. The epithelial-mesenchymal transition generates cells with properties of stem cells.

Authors: Sendurai A Mani; Wenjun Guo; Mai-Jing Liao; Elinor Ng Eaton; Ayyakkannu Ayyanan; Alicia Y Zhou; Mary Brooks; Ferenc Reinhard; Cheng Cheng Zhang; Michail Shipitsin; Lauren L Campbell; Kornelia Polyak; Cathrin Brisken; Jing Yang; Robert A Weinberg
Journal: Cell Date: 2008-05-16 Impact factor: 41.582

8. Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype.

Authors: Xiaolan Zhu; Huiling Shen; Xinming Yin; Meiling Yang; Hong Wei; Qi Chen; Fan Feng; Yueqin Liu; Wenlin Xu; Yuefeng Li
Journal: J Exp Clin Cancer Res Date: 2019-02-15

9. An integrated analysis to predict micro-RNAs targeting both stemness and metastasis in breast cancer stem cells.

Authors: Mahsa Rahimi; Ali Sharifi-Zarchi; Javad Firouzi; Mahnaz Azimi; Nosratollah Zarghami; Effat Alizadeh; Marzieh Ebrahimi
Journal: J Cell Mol Med Date: 2019-02-01 Impact factor: 5.310

10. The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells.

Authors: Catherine H Kaschula; Rosanna Tuveri; Ellen Ngarande; Kevin Dzobo; Christopher Barnett; Daniel A Kusza; Lisa M Graham; Arieh A Katz; Mohamed Suhail Rafudeen; M Iqbal Parker; Roger Hunter; Georgia Schäfer
Journal: BMC Cancer Date: 2019-03-20 Impact factor: 4.430

15 in total

1. Activation of GPER by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124/CD151 pathway.

Authors: Huaicheng Yang; Congyu Wang; Heqiang Liao; Qi Wang
Journal: Oncol Lett Date: 2021-03-31 Impact factor: 2.967

Review 2. Epithelial to Mesenchymal Transition: A Challenging Playground for Translational Research. Current Models and Focus on TWIST1 Relevance and Gastrointestinal Cancers.

Authors: Luana Greco; Federica Rubbino; Alessandra Morelli; Federica Gaiani; Fabio Grizzi; Gian Luigi de'Angelis; Alberto Malesci; Luigi Laghi
Journal: Int J Mol Sci Date: 2021-10-25 Impact factor: 5.923

3. Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p/CTBP2/E-cadherin axis in colorectal cancer.

Authors: Jiehua He; Ziqiang Chu; Wei Lai; Qiusheng Lan; Yujie Zeng; Daning Lu; Shaowen Jin; Heyang Xu; Pengwei Su; Dong Yin; Zhonghua Chu; Lu Liu
Journal: J Hematol Oncol Date: 2021-11-15 Impact factor: 17.388

MiRNA-mediated EMT and CSCs in cancer chemoresistance.

1. First Axl inhibitor enters clinical trials.

2. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis.

3. MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells.

Review 4. IGF1 receptor signaling pathways.

5. Extracellular vesicles released by mesenchymal-like prostate carcinoma cells modulate EMT state of recipient epithelial-like carcinoma cells through regulation of AR signaling.

6. Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells.

7. The epithelial-mesenchymal transition generates cells with properties of stem cells.

8. Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype.

9. An integrated analysis to predict micro-RNAs targeting both stemness and metastasis in breast cancer stem cells.

10. The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells.

1. Activation of GPER by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124/CD151 pathway.

Review 2. Epithelial to Mesenchymal Transition: A Challenging Playground for Translational Research. Current Models and Focus on TWIST1 Relevance and Gastrointestinal Cancers.

3. Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p/CTBP2/E-cadherin axis in colorectal cancer.

4. HOXA13 promotes gastric cancer progression partially via the FN1-mediated FAK/Src axis.

Review 5. The role of ncRNAs in neuroblastoma: mechanisms, biomarkers and therapeutic targets.

Review 6. Bone Marrow-Derived Cells in Endometrial Cancer Pathogenesis: Insights from Breast Cancer.

Review 7. Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies.

8. Tanshinone IIA attenuates the stemness of breast cancer cells via targeting the miR-125b/STARD13 axis.

9. miR-223-3p targets FBXW7 to promote epithelial-mesenchymal transition and metastasis in breast cancer.

Review 10. The regulation of PBXs and their emerging role in cancer.